Results 251 to 260 of about 6,328,527 (298)

An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman, Markus Englert, Kazuhito Akama   +2 more
wiley   +1 more source

Cryo-EM structures of ALECT2 filaments from human renal biopsies. [PDF]

Nat Commun
Zheng JL, Zheng YX, Chen K, Wang S, Liang JW, Wang SX, Yang L, Shi Y.   +7 more
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

KNexPHENIX: A PHENIX-Based Workflow for Improving Cryo-EM and Crystallographic Structural Models. [PDF]

J Chem Inf Model
Nandi S, Conn GL.
europepmc   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Cryo-EM structure of ALC1 in an open conformation bound to a PARylated nucleosome. [PDF]

Acta Crystallogr D Struct Biol
Bridges HR, Bacic L, Deindl S, Gaullier G.   +3 more
europepmc   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

Small, EarlyView.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim, Lingqing Zong, Wei Deng, Maria Kavallaris, Zi Gu   +4 more
wiley   +1 more source

Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15. [PDF]

Proc Natl Acad Sci U S A
Liang X, Pathak R, Qiu X, Dillard L, Twomey EC, Müller U.   +5 more
europepmc   +1 more source

CryoPromptSeg: prompt-guided segmentation with integrated denoising for cryo-EM particle picking. [PDF]

Bioinformatics
Yang B, You Y, Jin L, Yu H, Zhang L.
europepmc   +1 more source

Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin. [PDF]

Mol Cell
Li D, Wang X, Hao H, Eden J, Hu B, Walsh EE, Parson MAH, Hamill S, Li Y, Chen G, Burke JE, De Camilli P, Reinisch KM.   +12 more
europepmc   +1 more source