Results 241 to 250 of about 6,328,527 (298)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Making sense of invisible densities in single-particle cryo-EM. [PDF]

IUCrJ
Lin X, Cheng Y.
europepmc   +1 more source

Strigolactone signaling: Licensing antiviral RNA interference in rice

New Plant Protection, EarlyView.
Rice grassy stunt virus (RGSV) suppresses strigolactone‐mediated antiviral RNAi through P3‐D14 interaction. Structure‐guided D14D102N editing disrupts P3 binding while maintaining SL signaling, sustaining antiviral defense and providing strong resistance without compromising plant growth or yield.
Kaibo Gu, Yanjun Li
wiley   +1 more source

WebCalEM: a browser-based tool for routine and accurate pixel-size calibration in cryo-EM. [PDF]

Acta Crystallogr F Struct Biol Commun
Dang L, Wang Z, Cho SHJ, Li S, Chakraborty G, Fahim NF, Jiang W.   +6 more
europepmc   +1 more source

Enhance food plant diversity conservation and use through greater coordination between genebanks and botanic gardens

PLANTS, PEOPLE, PLANET, EarlyView.
Food plants are vital to human and planetary health, but their diversity is threatened, making food security, nutrition, and environmental goals more difficult to achieve. Food plant diversity conservation, research, and education can be enhanced through collaboration between sectors, including genebanks and botanic gardens, which possess complementary
Colin K. Khoury, Sarah Gora, Hannes Dempewolf, Mauricio Diazgranados, Alex C. McAlvay, Vania Azevedo, Sam Brockington, Ángela Cano, Daniel Carver, Carly Cowell, Peter Crane, Cary Fowler, Peter Giovannini, Luigi Guarino, Robbie Hart, Geoff Hawtin, Sarada Krishnan, Charlotte Lusty, Patricia Malcolm, Nan McCarry, Abby Meyer, Allison Miller, Ray Mims, Tara Moreau, Arshiya Noorani, Susan K. Pell, Juan Lucas Restrepo, Erin C. Riordan, Stefan Schmitz, Paul Smith, Charles Spillane, Alvaro Toledo, Raakel Toppila, Maarten van Zonneveld, Emily Warschefsky, Peter Wenzl   +35 more
wiley   +1 more source

An unattended image-processing pipeline for on-the-fly quality assessment and 3D exploration in cryo-EM. [PDF]

Acta Crystallogr D Struct Biol
Marchán Torres D, Conesa P, Garcia A, Iceta M, Broche L, Gragera M, Linares R, Kwong HS, Chichón FJ, Svensson O, Arranz R, Effantin G, Kandiah E, Carazo JM, Sorzano COS.   +14 more
europepmc   +1 more source

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

Cryo-EM structure of the complex between transglutaminase 2 and the 45 kDa domain of fibronectin. [PDF]

J Biol Chem
Heggelund JE, Ali-Ahmad A, Johannesen MK, Sekulić N, Sollid LM.   +4 more
europepmc   +1 more source

Performance of pyDock in 8th CAPRI: Energy‐Based Scoring Applied to Docking and AlphaFold Models

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The 8th CAPRI edition has shown a significant evolution in the field of protein–protein complex structure prediction. We have participated in all 11 targets proposed in this edition, involving domain‐domain, protein–protein, protein‐peptide, and protein‐DNA interactions, including homo‐ and hetero‐meric interfaces.
Luis Angel Rodríguez‐Lumbreras, Mireia Rosell, Miguel Romero‐Durana, Víctor Monteagudo, Fabian Glaser, Juan Fernandez‐Recio   +5 more
wiley   +1 more source

Cryo-EM structures of multiple-peptide resistance factor (MprF) from Pseudomonas aeruginosa. [PDF]

FEBS J
Jha S, Vinothkumar KR.
europepmc   +1 more source