Results 91 to 100 of about 22,654 (207)

Howard Hughes Medical Institute 2013 Year in Review [PDF]

, 2014
The Howard Hughes Medical Institute is the nation's largest private supporter of academic biomedical research. As a medical research organization, the Institute spends at least 3.5 percent of its endowment each year on research activities and related ...

core  

Protocol for the purification of replisomes from the Xenopus laevis egg extract system for single-particle cryo-EM analysis

STAR Protocols
Summary: Here, we present a large-scale FLAG immunoprecipitation protocol to isolate large protein complexes driving DNA replication at replicating chromatin assembled in Xenopus laevis egg extract.
Paolo Passaretti, Milos A. Cvetkovic, Alessandro Costa, Agnieszka Gambus   +3 more
doaj   +1 more source

Advances in Structure Modeling Methods for Cryo-Electron Microscopy Maps

Molecules, 2019
Cryo-electron microscopy (cryo-EM) has now become a widely used technique for structure determination of macromolecular complexes. For modeling molecular structures from density maps of different resolutions, many algorithms have been developed.
Eman Alnabati, Daisuke Kihara
doaj   +1 more source

An assessment of the resolution limitation due to radiation-damage in x-ray diffraction microscopy

, 2005
X-ray diffraction microscopy (XDM) is a new form of x-ray imaging that is being practiced at several third-generation synchrotron-radiation x-ray facilities.
Barty, Baruchel, Beetz, Burmeister, C. Cui, C.J. Jacobsen, Chapman, Chapman, D. Sayre, D. Starodub, D.A. Shapiro, E. Lima, Elser, Fienup, Franck, Garman, Garman, Gerchberg, Glaeser, Glaeser, Glaeser, Goodman, H. Miao, H.N. Chapman, Hayward, Hegerl, Henderson, Henderson, Henke, J. Kirz, J.C.H. Spence, J.M. Holton, Jacobsen, Kirz, Kmetko, London, M.R. Howells, Marchesini, Marchesini, Maser, McEwen, Medalia, Miao, Miao, Miao, Miao, Mueller, Nave, Neutze, Owen, Plitzko, Ravelli, Reimer, Robinson, Rodenburg, Rudolph, S. Marchesini, Sayre, Sayre, Sayre, Schlotter, Schneider, Shapiro, Shen, Sliz, Spence, Spence, Starodub, T. Beetz, Williams, Zhang   +70 more
core   +1 more source

Cryoelectron microscopy of low density lipoprotein in vitreous ice

Biophysical Journal, 1995
In this report, images of low density lipoprotein (LDL) in vitreous ice at approximately 30 A resolution are presented. These images show that LDL is a quasi-spherical particle, approximately 220-240 A in diameter, with a region of low density (lipid) surrounded by a ring (in projection) of high density believed to represent apolipoprotein B-100.
Spin, J.M., Atkinson, D.
openaire   +2 more sources

Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of maternal–foetal communication, regulating placental function and foetal development through the transfer of bioactive molecules. Although placental EVs play a crucial role in placental function during pregnancy, their contribution to foetal development, notably foetal brain, remains poorly ...
Charlène Martin, Hélène Martin, Mathilde Bergamelli, Lhorane Lobjois, Lucie Franco, Emma Bordes, Alexandra Benchoua, Stéphanie Balor, Diala Kantar, Etienne Coyaud, Frédéric Martins, Alexandre Favereaux, Cécile E. Malnou   +12 more
wiley   +1 more source

Exploring the protein universe with distant similarity detection methods

Protein Science, Volume 35, Issue 1, January 2026.
Abstract During the last few years, the body of data on proteins is expanding almost exponentially with the development of advanced methods for gene sequencing, protein structure determination, particularly by cryoelectron microscopy, and structure prediction using artificial intelligence‐based approaches.
Harutyun Sahakyan, Pascal Mutz, Victor Tobiasson, Eugene V. Koonin   +3 more
wiley   +1 more source

Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge

Cell Reports
Summary: Recent reports highlight the efficacy of engineered mycobacteriophages to treat non-tuberculosis mycobacterial disease. Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering ...
Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho   +20 more
doaj   +1 more source

A Critical Evaluation of Nano‐ and Microplastics: Sources, Health Risks, and Mitigation Strategies

Advances in Materials Science and Engineering, Volume 2026, Issue 1, 2026.
Microplastics (1 μm–5 mm) and nanoplastics (< 1 μm) have become ubiquitous contaminants across air, water, and soil systems, with growing evidence of their presence in human tissues including blood, lungs, and even the placenta. While microplastics have been extensively studied, nanoplastics remain poorly understood because of their minute size and ...
George G. Njema, Mojeed A. Agoro, Joshua K. Kibet, Mohammad Rezwan Habib   +3 more
wiley   +1 more source

Symmetry-guided nonrigid registration: the case for distortion correction in multidimensional photoemission spectroscopy

, 2019
Image symmetrization is an effective strategy to correct symmetry distortion in experimental data for which symmetry is essential in the subsequent analysis.
Ernstorfer, Ralph, Rettig, Laurenz, Xian, Rui Patrick   +2 more
core   +1 more source