Results 81 to 90 of about 22,940 (199)
, 1993 Given our current understanding of nuclear structure, it is difficult to imagine how the nucleus performs its varied functions and controls the traffic of its many components.
Dubochet, J.
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Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming +4 more
wiley +1 more source
Automated cryoelectron microscopy of “single particles” applied to the 26S proteasome [PDF]
FEBS Letters, 2007 The 26S proteasome is a large molecular machine with a central role in intracellular protein degradation in eukaryotes. The 2.5 MDa complex, which is built from two copies each of more than 30 different subunits, is labile and prone to dissociation into subcomplexes.
Nickell, S. +5 more
openaire +3 more sources
Precise Capture of Membrane Proteins Using DNA‐Origami‐Constrained Nanodiscs
Small Structures, Volume 7, Issue 4, April 2026.A designed DNA origami structure ensures manipulates and inserts an individual membrane protein in a single, captured nanodisc. Membrane proteins play a key role as cellular gatekeepers, regulating the flow of information and material across lipid membranes.
Piotr Stepien +7 more
wiley +1 more source
A heterologous expression system for bovine lens transmembrane main intrinsic protein (MIP) in Nicotiana tabacum plants [PDF]
, 1999 We have developed a heterologous expression system for transmembrane lens main intrinsic protein (MIP) in Nicotiana tabacum plant tissue. A native bovine MIP26 amplicon was subcloned into an expression cassette under the control of a constitutive ...
Crabbe, M. J. C. +3 more
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Radial distribution of RNA genome packaged inside spherical viruses
, 2008 The problem of RNA genomes packaged inside spherical viruses is studied. The viral capsid is modeled as a hollowed sphere. The attraction between RNA molecules and the inner viral capsid is assumed to be non-specific and occurs at the inner capsid ...
J. Johnson +3 more
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Surface topography of microtubule walls decorated with monomeric and dimeric kinesin constructs [PDF]
, 2000 The surface topography of opened-up microtubule walls (sheets) decorated with monomeric and dimeric kinesin motor domains was investigated by freeze-drying and unidirectional metal shadowing.
Doerhoefer, Monika +6 more
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Structures of pentatricopeptide repeat proteins
Acta Crystallographica Section F, Volume 82, Issue 4, Page 101-113, April 2026.A number of crystal, cryo‐EM and solution structures of pentatricopeptide repeat proteins have been solved, revealing details of how they interact with single‐stranded RNA and other proteins, as well as their conformational repertoire.Pentatricopeptide repeat (PPR) proteins constitute the largest family of RNA‐binding proteins in land plants, playing ...
Anuradha Pullakhandam +3 more
wiley +1 more source
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
Cell Reports, 2019 Summary: LSD1 and LSD2 are homologous histone demethylases with opposite biological outcomes related to chromatin silencing and transcription elongation, respectively.
Chiara Marabelli +12 more
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Cryo-electron microscopy structures of pyrene-labeled ADP-Pi- and ADP-actin filaments
Nature Communications, 2020 For almost forty years, N-(1-pyrene) iodoacetamide has been used to label actin at C374, but the mechanisms of the fluorescence changes are still unknown due to the lack of structural information.
Steven Z. Chou, Thomas D. Pollard
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