Results 61 to 70 of about 22,940 (199)
Analytic modeling of inhomogeneous-resolution maps in cryo-electron microscopy and crystallography
IUCrJ, 2022 Refinement of macromolecular atomic models versus experimental maps in crystallography and cryo-electron microscopy is a critical step in structure solution.
Alexandre Urzhumtsev, Vladimir Y. Lunin
doaj +1 more source
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Aggregate, Volume 7, Issue 6, June 2026.This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian +5 more
wiley +1 more source
Postsynaptic protein organization revealed by electron microscopy. [PDF]
, 2019 Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the ...
Bi, Guo-Qiang +4 more
core
Acta Crystallographica Section D, Volume 82, Issue 6, Page 638-645, June 2026.We present a quantitative framework combining cost modelling and queueing theory to estimate hourly access costs, waiting times and congestion levels for shared high‐end scientific equipment. The approach is general, illustrated with cryo‐electron microscopy examples, and implemented in an open‐access online calculator to support evidence‐based ...
C. O. S. Sorzano, J. M. Carazo
wiley +1 more source
Using cryo-electron microscopy maps for X-ray structure determination
IUCrJ, 2018 X-ray crystallography and cryo-electron microscopy (cryo-EM) are complementary techniques for structure determination. Crystallography usually reveals more detailed information, while cryo-EM is an extremely useful technique for studying large-sized ...
Lingxiao Zeng, Wei Ding, Quan Hao
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Cryo‐EM structure of ALC1 in an open conformation bound to a PARylated nucleosome
Acta Crystallographica Section D, Volume 82, Issue 6, Page 683-699, June 2026.Reanalysis of a publicly available cryo‐EM dataset identifies a new conformation of the oncogenic chromatin remodeler ALC1/CHD1L bound to a PARylated nucleosome. This new structure reveals the position of the macro domain in the complex, and may help to understand the large conformational change leading to the activation of ALC1.Nucleosomes are the ...
Hannah R. Bridges +3 more
wiley +1 more source
Cryo-electron microscopy of extracellular vesicles in fresh plasma
Journal of Extracellular Vesicles, 2013 Introduction: Extracellular vesicles (EV) are phospholipid bilayer-enclosed vesicles recognized as new mediators in intercellular communication and potential biomarkers of disease.
Yuana Yuana +6 more
doaj +1 more source
Cryo-electron Microscopy Analysis of Structurally Heterogeneous Macromolecular Complexes
Computational and Structural Biotechnology Journal, 2016 Cryo-electron microscopy (cryo-EM) has for a long time been a technique of choice for determining structure of large and flexible macromolecular complexes that were difficult to study by other experimental techniques such as X-ray crystallography or ...
Slavica Jonić
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Preparation of Doublet Microtubule Fraction for Single Particle Cryo-electron Microscopy
Bio-Protocol, 2021 Over the years, studying the ultrastructure of the eukaryotic cilia/flagella using electron microscopy (EM) has contributed significantly toward our understanding of ciliary function.
Corbin Black +4 more
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