Results 61 to 70 of about 22,654 (207)
Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography [PDF]
, 2008 Electron tomography is currently the highest resolution imaging modality available to study the 3D structures of pleomorphic macromolecular assemblies, viruses, organelles and cells. Unfortunately, the resolution is currently limited to 3–5 nm by several
Castaño-Díez, Daniel +8 more
core +1 more source
Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective
Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming +4 more
wiley +1 more source
Using cryo-electron microscopy maps for X-ray structure determination
IUCrJ, 2018 X-ray crystallography and cryo-electron microscopy (cryo-EM) are complementary techniques for structure determination. Crystallography usually reveals more detailed information, while cryo-EM is an extremely useful technique for studying large-sized ...
Lingxiao Zeng, Wei Ding, Quan Hao
doaj +1 more source
Membrane-associated proteins in giardia lamblia [PDF]
, 2018 The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza +2 more
core +1 more source
Precise Capture of Membrane Proteins Using DNA‐Origami‐Constrained Nanodiscs
Small Structures, Volume 7, Issue 4, April 2026.A designed DNA origami structure ensures manipulates and inserts an individual membrane protein in a single, captured nanodisc. Membrane proteins play a key role as cellular gatekeepers, regulating the flow of information and material across lipid membranes.
Piotr Stepien +7 more
wiley +1 more source
Cryo-electron microscopy of extracellular vesicles in fresh plasma
Journal of Extracellular Vesicles, 2013 Introduction: Extracellular vesicles (EV) are phospholipid bilayer-enclosed vesicles recognized as new mediators in intercellular communication and potential biomarkers of disease.
Yuana Yuana +6 more
doaj +1 more source
Cryo-electron Microscopy Analysis of Structurally Heterogeneous Macromolecular Complexes
Computational and Structural Biotechnology Journal, 2016 Cryo-electron microscopy (cryo-EM) has for a long time been a technique of choice for determining structure of large and flexible macromolecular complexes that were difficult to study by other experimental techniques such as X-ray crystallography or ...
Slavica Jonić
doaj +1 more source
Preparation of Doublet Microtubule Fraction for Single Particle Cryo-electron Microscopy
Bio-Protocol, 2021 Over the years, studying the ultrastructure of the eukaryotic cilia/flagella using electron microscopy (EM) has contributed significantly toward our understanding of ciliary function.
Corbin Black +4 more
doaj +1 more source
, 1993 Given our current understanding of nuclear structure, it is difficult to imagine how the nucleus performs its varied functions and controls the traffic of its many components.
Dubochet, J.
core +1 more source
Structures of pentatricopeptide repeat proteins
Acta Crystallographica Section F, Volume 82, Issue 4, Page 101-113, April 2026.A number of crystal, cryo‐EM and solution structures of pentatricopeptide repeat proteins have been solved, revealing details of how they interact with single‐stranded RNA and other proteins, as well as their conformational repertoire.Pentatricopeptide repeat (PPR) proteins constitute the largest family of RNA‐binding proteins in land plants, playing ...
Anuradha Pullakhandam +3 more
wiley +1 more source