Results 51 to 60 of about 22,654 (207)
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]
, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Balogun, Rilwan +9 more
core +2 more sources
Acta Crystallographica Section D, EarlyView.We present a quantitative framework combining cost modelling and queueing theory to estimate hourly access costs, waiting times and congestion levels for shared high‐end scientific equipment. The approach is general, illustrated with cryo‐electron microscopy examples, and implemented in an open‐access online calculator to support evidence‐based ...
C. O. S. Sorzano, J. M. Carazo
wiley +1 more source
Some Like It Hot –Structural Changes in Extremophile Rubredoxin at 120 °C
Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.We reveal the high temperature crystal structure of a hyperthermophilic (Pyrococcus furiosus) rubredoxin at 393 K (120 °C), together with multiple complementary structures down to 100 K. The results are compared with molecular dynamics calculations. Significant changes in H‐bonding are observed.
Tzanko Doukov +4 more
wiley +2 more sources
Analytic modeling of inhomogeneous-resolution maps in cryo-electron microscopy and crystallography
IUCrJ, 2022 Refinement of macromolecular atomic models versus experimental maps in crystallography and cryo-electron microscopy is a critical step in structure solution.
Alexandre Urzhumtsev, Vladimir Y. Lunin
doaj +1 more source
Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]
, 2019 As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M +2 more
core +1 more source
, 2019 Lipid droplets (LDs) are ubiquitous organelles comprising a central hub for cellular lipid metabolism and trafficking. This role is tightly associated with their interactions with several cellular organelles.
Arnold, J. +6 more
core +1 more source
Tropomyosin Positions in Regulated Thin Filaments Revealed by Cryoelectron Microscopy [PDF]
Biophysical Journal, 1999 Past attempts to detect tropomyosin in electron micrograph images of frozen-hydrated troponin-regulated thin filaments under relaxing conditions have not been successful. This raised the possibility that tropomyosin may be disordered on filaments in the off-state, a possibility at odds with the steric blocking model of muscle regulation.
Xu, C. +4 more
openaire +2 more sources
Damage‐limited resolution for X‐ray and electron microscopy of organic specimens
Acta Crystallographica Section D, Volume 82, Issue 5, Page 471-483, May 2026.Analytical expressions for the damage‐limited resolution are developed and applied to X‐ray and electron imaging of beam‐sensitive specimens. The findings will guide future microscopy and instrument design.Analytical expressions for the damage‐limited resolution (DLR) are developed and applied to X‐ray and electron imaging of beam‐sensitive specimens ...
Ray F. Egerton, Colin Nave
wiley +1 more source
Postsynaptic protein organization revealed by electron microscopy. [PDF]
, 2019 Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the ...
Bi, Guo-Qiang +4 more
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