Results 51 to 60 of about 17,043 (166)

Research progress on the structure and function of the type IX secretion system of Porphyromonas gingivalis

open access: yes口腔疾病防治, 2023
The Porphyromonas gingivalis type IX secretion system (T9SS) is a recently discovered protein secretion system that is widely distributed in Bacillus cereus. The T9SS is structurally complex and powerful.
ZHANG Ruotong, YE Wei
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

open access: yesAnimal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu   +8 more
wiley   +1 more source

mmCIF Validator: a comprehensive validation tool for structural biology data files

open access: yesJournal of Applied Crystallography, EarlyView.
The mmCIF Validator provides real‐time automated validation of mmCIFs against a valid PDBx/mmCIF dictionary. The validator is available as both a Visual Studio Code extension and a standalone Python script for integration into automated workflows.The PDBx/macromolecular crystallographic information file (PDBx/mmCIF) framework is the standard for ...
Deborah Harrus   +5 more
wiley   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

open access: yesInterdisciplinary Medicine, Volume 4, Issue 4, July 2026.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang   +10 more
wiley   +1 more source

Mapping the Conformational Landscape of DNA Minicircles Through Atomic Force Microscopy and Shape Space Analysis

open access: yesSmall, Volume 22, Issue 37, 2 July 2026.
An automated framework is presented for quantifying DNA conformational variability from atomic force microscopy (AFM) images. DNA backbones are reduced to spline representations and analyzed using cyclic Procrustes analysis to measure shape similarity across ensembles.
Laura Wiggins   +7 more
wiley   +1 more source

Analytic modeling of inhomogeneous-resolution maps in cryo-electron microscopy and crystallography

open access: yesIUCrJ, 2022
Refinement of macromolecular atomic models versus experimental maps in crystallography and cryo-electron microscopy is a critical step in structure solution.
Alexandre Urzhumtsev, Vladimir Y. Lunin
doaj   +1 more source

Assessing protein‐specific radiation damage in time‐resolved X‐ray solution‐scattering experiments at high‐brilliance synchrotrons using fast detector readout

open access: yesActa Crystallographica Section D, Volume 82, Issue 7, Page 715-726, July 2026.
Adenylate kinase was used to quantify how experimental parameters influence radiation damage during time‐resolved X‐ray solution scattering (TR‐XSS) at a multipurpose SAXS beamline. The study provides general guidelines for minimizing radiation artifacts in TR‐XSS.Time‐resolved X‐ray solution scattering (TR‐XSS) enables tracking of protein structural ...
Fatemeh Sabzian-Molaei   +2 more
wiley   +1 more source

Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.

open access: yesPLoS ONE, 2018
Protein arginine methyl transferase 5 (PRMT5) is a signaling protein and histone modifying enzyme that is important in many cellular processes, including regulation of eukaryotic gene transcription.
David E Timm   +3 more
doaj   +1 more source

Wave Mechanics of Ciliary Proteins: Quantum‐Enabled Sensing and Energy Transfer in the “Cellular Antenna”

open access: yesAggregate, Volume 7, Issue 6, June 2026.
This review surveys eukaryotic cilia as putative quantum‐enabled sensory and regulatory centers. It highlights their multifaceted roles in the cell, focuses on the nontrivial roles of quantum mechanics in their membrane and cytoskeletal proteins, and introduces the essential building blocks enabling quantum properties to survive in the warm, wet, and ...
Daniel L. Bilezikian   +5 more
wiley   +1 more source

Cryo-electron microscopy of extracellular vesicles in fresh plasma

open access: yesJournal of Extracellular Vesicles, 2013
Introduction: Extracellular vesicles (EV) are phospholipid bilayer-enclosed vesicles recognized as new mediators in intercellular communication and potential biomarkers of disease.
Yuana Yuana   +6 more
doaj   +1 more source

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