Results 31 to 40 of about 22,654 (207)

Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes

Cell Reports, 2021
Summary: The glucagon-like peptide-1 receptor (GLP-1R) regulates insulin secretion, carbohydrate metabolism, and appetite and is an important target for treatment of type 2 diabetes and obesity. Multiple GLP-1R agonists have entered into clinical trials,
Xin Zhang, Matthew J. Belousoff, Yi-Lynn Liang, Radostin Danev, Patrick M. Sexton, Denise Wootten   +5 more
doaj   +1 more source

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

3D visualization of HIV virions by cryoelectron tomography. [PDF]

, 2010
The structure of the human immunodeficiency virus (HIV) and some of its components have been difficult to study in three-dimensions (3D) primarily because of their intrinsic structural variability.
Accola, Arthur, Bartesaghi, Baumeister, Beck, Benjamin, Briggs, Briggs, Briggs, Briggs, Briggs, Burton, Byeon, Chan, Chen, Chen, Dai, Douglas, Dubochet, Frangakis, Freed, Fuller, Förster, Förster, Ganser, Ganser, Ganser-Pornillos, Gay, Gelderblom, Gross, Grunewald, Harauz, Heymann, Huang, Koster, Koster, Kremer, Kwong, Lanman, Lanman, Li, Li, Liang, Liu, Liu, Liu, Lucic, Ludtke, Massiah, Massiah, Mastronarde, McEwen, Medalia, Murphy, Nermut, Nickell, Pancera, Penczek, Pettersen, Pornillos, Sougrat, Subramaniam, Subramaniam, Suloway, Walz, Wilk, Winkler, Winkler, Winkler, Wright, Ye, Zanetti, Zheng, Zhou, Zhou, Zhu, Zhu, Zhu   +77 more
core   +1 more source

Correlative light electron microscopy of giant viruses with the SECOM system

New Microbes and New Infections, 2018
Bright-field transmission electron microscopy (TEM), TEM-negative staining technique, resin-embedding and ultramicrotomy, scanning TEM, scanning electron microscopy, atomic force microscopy and cryoelectron microscopy are imaging techniques used for ...
J.-P. Baudoin, S. Hari, D. Sahmi-Bounsiar, S.I. Traore, J. Bou-Khalil, J. Andréani, B. La Scola   +6 more
doaj   +1 more source

Recent advances in retroviruses via cryo-electron microscopy

Retrovirology, 2018
Cryo-electron microscopy has undergone a revolution in recent years and it has contributed significantly to a number of different areas in biological research.
Johnson Mak, Alex de Marco
doaj   +1 more source

Morphology of influenza B/Lee/40 determined by cryo-electron microscopy. [PDF]

PLoS ONE, 2014
Cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza B/Lee/40. Algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of
Garrett Katz, Younes Benkarroum, Hui Wei, William J Rice, Doris Bucher, Alexandra Alimova, Al Katz, Joanna Klukowska, Gabor T Herman, Paul Gottlieb   +9 more
doaj   +1 more source

Membrane shape as a reporter for applied forces [PDF]

, 2008
Recent advances have enabled 3-dimensional reconstructions of biological structures in vivo, ranging in size and complexity from single proteins to multicellular structures. In particular, tomography and confocal microscopy have been exploited to capture
Antonny, Canham, Cheng, E. L. Peterson, Evans, Fertuck, Frey, Gerlich, H. J. Lee, Heinrich, Jenkins, Kusumi, Ledesma, Mills, Neuman, P. A. Wiggins, R. Phillips, Rawicz, Razani, Rodriguez-Boulan, Sheetz, Singer, Sougrat, Tian, Unwin, Upadhyaya, Vale, W. S. Klug, Waterman-Storer, Waugh, Waugh   +30 more
core   +2 more sources

Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid.

PLoS ONE, 2020
Extracellular vesicles (EVs) are membrane-enclosed vesicles which play important role for cell communication and physiology. EVs are found in many human biological fluids, including blood, breast milk, urine, cerebrospinal fluid (CSF), ejaculate, saliva ...
Anton Emelyanov, Tatiana Shtam, Roman Kamyshinsky, Luiza Garaeva, Nikolai Verlov, Irina Miliukhina, Anastasia Kudrevatykh, Gaspar Gavrilov, Yulia Zabrodskaya, Sofya Pchelina, Andrey Konevega   +10 more
doaj   +1 more source

Learning to automate cryo-electron microscopy data collection with Ptolemy

IUCrJ, 2023
Over the past decade, cryo-electron microscopy (cryoEM) has emerged as an important method for determining near-native, near-atomic resolution 3D structures of biological macromolecules.
Paul T. Kim, Alex J. Noble, Anchi Cheng, Tristan Bepler   +3 more
doaj   +1 more source

Lensfree super-resolution holographic microscopy using wetting films on a chip. [PDF]

, 2011
We investigate the use of wetting films to significantly improve the imaging performance of lensfree pixel super-resolution on-chip microscopy, achieving < 1 µm spatial resolution over a large imaging area of ~24 mm(2).
Bishara, Waheb, Mudanyali, Onur, Ozcan, Aydogan   +2 more
core   +1 more source