Results 21 to 30 of about 1,110,843 (197)

Mechanistic understanding of human SLFN11

Nature Communications, 2022
Schlafen 11 serves as an antiviral restriction factor and a predictive biomarker in cancer. Here, the authors use cryoelectron microscopy and biochemical assays to understand tRNA endoribonuclease and DNA binding functions of human Schlafen 11.
Felix J. Metzner, Simon J. Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens   +5 more
doaj   +1 more source

Solution-processable and functionalizable ultra-high molecular weight polymers via topochemical synthesis

Nature Communications, 2021
Topochemical polymerization reactions produce ultra-high molecular weight crystalline polymers. Here the authors show a family of para-azaquinodimethane compounds that undergo facile visible light and thermally initiated polymerization in the solid state
Christopher L. Anderson, He Li, Christopher G. Jones, Simon J. Teat, Nicholas S. Settineri, Eric A. Dailing, Jiatao Liang, Haiyan Mao, Chongqing Yang, Liana M. Klivansky, Xinle Li, Jeffrey A. Reimer, Hosea M. Nelson, Yi Liu   +13 more
doaj   +1 more source

CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy. [PDF]

Proc Natl Acad Sci U S A
Structural biology is experiencing a paradigm shift from targeted structural determination to structure-guided discovery of previously uncharacterized bioentities. We employed cryoelectron microscopy (cryo-EM) to analyze filtered water samples collected from the Tsinghua Lotus Pond.
Wang T, Li Z, Xu K, Huang W, Huang G, Zhang QC, Yan N.   +6 more
europepmc   +3 more sources

Structure of the p53/RNA polymerase II assembly

Communications Biology, 2021
Liou et al. report a 4.6 Å resolution structure of the human p53/ RNA polymerase II assembly, using single particle cryoelectron microscopy. This study suggests that p53’s functional domains regulate the DNA binding activity of RNA polymerase II ...
Shu-Hao Liou, Sameer K. Singh, Robert H. Singer, Robert A. Coleman, Wei-Li Liu   +4 more
doaj   +1 more source

Oxygen-Sensitive Metalloprotein Structure Determination by Cryo-Electron Microscopy

Biomolecules, 2022
Metalloproteins are involved in key cell processes such as photosynthesis, respiration, and oxygen transport. However, the presence of transition metals (notably iron as a component of [Fe-S] clusters) often makes these proteins sensitive to oxygen ...
Mickaël V. Cherrier, Xavier Vernède, Daphna Fenel, Lydie Martin, Benoit Arragain, Emmanuelle Neumann, Juan C. Fontecilla-Camps, Guy Schoehn, Yvain Nicolet   +8 more
doaj   +1 more source

Cryoelectron Microscopy Reconstructions of the Pseudomonas aeruginosa and Neisseria gonorrhoeae Type IV Pili at Sub-nanometer Resolution [PDF]

Structure, 2017
Mathieu Coureuil, Lisa Craig, Tomasz Osiński   +2 more
exaly   +2 more sources

Fibril structure of amyloid-ß(1-42) by cryoelectron microscopy [PDF]

, 2017
Amyloids are implicated in neurodegenerative diseases. Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile plaques found in brains of Alzheimer’s disease patients.
Hoyer, Wolfgang, Jörg Labahn, Tusche, Markus, Lothar Gremer, Carmen Lopez-Iglesias, Daniel Schölzel, Gunnar F. Schröder, Henrike Heise, Schröder, Gunnar, Markus Tusche, Raimond B. G. Ravelli, Carla Schenk, Schölzel, Daniel, Gremer, Lothar, Labahn, Joerg, Reinartz, Elke, Schoelzel, Daniel, Wolfgang Hoyer, Willbold, Dieter, Schenk, Carla, Ravelli, Raimond B. G., Elke Reinartz, Schröder, Gunnar F., Lopez-Iglesias, Carmen, Labahn, Jörg, Heise, Henrike, Dieter Willbold   +26 more
core   +2 more sources

Structure of the CLC-1 chloride channel from Homo sapiens

eLife, 2018
CLC channels mediate passive Cl− conduction, while CLC transporters mediate active Cl− transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence.
Eunyong Park, Roderick MacKinnon
doaj   +1 more source

Nanoscale characterization of the biomolecular corona by cryo-electron microscopy, cryo-electron tomography, and image simulation

Nature Communications, 2021
Understanding the biomolecular corona is of key importance to nanomedicine. Here, the authors report on cryo-electron and tomographic imaging of the corona formed on model nanoparticles and the 3D reconstruction of the corona to study the distribution ...
Sara Sheibani, Kaustuv Basu, Ali Farnudi, Aliakbar Ashkarran, Muneyoshi Ichikawa, John F. Presley, Khanh Huy Bui, Mohammad Reza Ejtehadi, Hojatollah Vali, Morteza Mahmoudi   +9 more
doaj   +1 more source

Structure of intracellular mature vaccinia virus observed by cryoelectron microscopy.

, 1994
Intracellular mature vaccinia virus, also called intracellular naked virus, and its core envelope have been observed in their native, unfixed, unstained, hydrated states by cryoelectron microscopy of vitrified samples.
Adrian, M., Richter, K., Dubochet, J., Wittek, R., Garces, J.   +4 more
core   +4 more sources