Results 101 to 110 of about 163,089 (384)
Apoptotic Cell Death and Function of Cryopreserved Porcine Hepatocytes in a Bioartificial Liver
Cell Transplantation, 2003 We have previously shown that cryopreservation leads to increased apoptotic death of porcine hepatocytes intended for use in a bioartificial liver (BAL).
Takakazu Matsushita +7 more
doaj +1 more source
Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma
Advanced Science, EarlyView.Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning +11 more
wiley +1 more source
Cryopreservation of plant germplasm in Argentina [PDF]
, 2007 This review describes the current status of development of methods for cryopreservation (at -196ºC) of plants germplasm in Argentina. Arachis pintoi, a forage legume, has been maintained as seeds using vitrification method. Additionally, apical meristems,
Mroginski, Luis Amado +1 more
core
Advanced Science, EarlyView.This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian +7 more
wiley +1 more source
Advanced Science, EarlyView.Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wenhao Wang +14 more
wiley +1 more source
Fertility Cryopreservation [PDF]
, 2010 Protecting the reproductive potential of young patients undergoing cancer therapy is increasingly important. With modern treatment protocols, 80% of patients can be expected to survive. It has been estimated that up to one in 250 young adults will be a survivor of childhood cancer in the future; infertility, however, may be a consequence.
Patrick Quinn, Ri-Cheng Chian
openaire +2 more sources
Fatherhood and sperm DNA damage in testicular cancer patients [PDF]
, 2018 Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility.
Lenzi, Andrea +3 more
core +1 more source
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
MODELING OF THE KINETICS OF CRYOGENIC FREEZING OF LIMA BEAN SEEDS AS A FUNCTION OF INITIAL WATER CONTENT [PDF]
Engenharia AgrícolaCryopreservation is a technique used to preserve genetic material at ultra-low temperatures in cryogenic germplasm banks. In order to enable the cryopreservation of a seed, it is necessary to study its appropriate freezing temperature and its water ...
Karina M da F. Luciano +3 more
doaj +2 more sources
Advanced Science, EarlyView.Cryogenic self‐assembly of lyotropic liquid crystals is achieved using alkyl alkanolamide amphiphiles in a 1,2‐propanediol/water cosolvent system. The hydrocarbon chain length significantly affects the molecular arrangement in bilayers and their long‐range orientational ordering.
Weiluo Guo +8 more
wiley +1 more source