Advanced Science, EarlyView.This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen +11 more
wiley +1 more source
Human oocytes and zygotes are ready for ultra-fast vitrification after 2 minutes of exposure to standard CPA solutions [PDF]
, 2019 Vitrification of human oocytes and embryos in different stages of development is a key element of daily clinical practice of in vitro fertilization treatments.
Gallardo Molina, Miguel +2 more
core +1 more source
Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells
Nature Communications, 2020 Natural killer (NK) cells are important effector cells in the immune response to cancer. Clinical trials on adoptively transferred NK cells in patients with solid tumors, however, have thus far been unsuccessful. As NK cells need to pass stringent safety
C. Mark +13 more
semanticscholar +1 more source
Advanced Science, EarlyView.A self‐developed CTC sorting and capture platform enabled single‐cell metabolomics of patient/animal CTCs, revealing brain/bone metastasis‐specific metabolic signatures. A classification model developed from these signatures predicted lung cancer metastasis risk, outperforming traditional markers and total CTC counts (AUCs:89 brain = 0.74; bone = 0.92).
Yang Xu +14 more
wiley +1 more source
The implementation of persuasive technology principles in mobile application development: a qualitative study [PDF]
, 2012 Preceding studies of persuasive technology have mentioned several benefits on the implementation of persuasive design features of the Persuasive System Design (PSD) model such as creating users' engagement and acceptance and continuous usage.
Abd Rahim, Mohd Hilmi Izwan +4 more
core +3 more sources
A Charge‐Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease
Advanced Science, EarlyView.DNA gel bandage (DNAgb) is designed to precisely target the site of inflammation of IBD, by achieving dual specific localization of inflamed mucosa through electrostatic interactions and ApITGA4‐mediated affinity targeting. DNAgb effectively the activation of inflammatory pathways and reshapes the immune microenvironment.
Peifen Lu +9 more
wiley +1 more source
In Vitro Fertility of Post-thawed Epididymal Ram Spermatozoa After Storage at 5 °C Before Cryopreservation [PDF]
, 2013 This study addressed the effects of storage duration of epididymides at 5 °C before sperm collection and their fertility after cryopreservation in vitro.
fahrudin, M. (M) +2 more
core
Fatherhood and sperm DNA damage in testicular cancer patients [PDF]
, 2018 Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility.
Lenzi, Andrea +3 more
core +1 more source
A comparative study of human ovarian tissue xenotransplantation in two different strains of rats
Animal Models and Experimental Medicine, EarlyView.The study involved performing ovariectomy on female Hooded and Wistar rats 14 days prior to transplantation. Following ovariectomy, the rats received cyclosporine starting five days before surgery to suppress the immune response and prevent graft rejection.
Mohammad Ayoubipour +5 more
wiley +1 more source
Texture profile analysis reveals a stiffer ovarian cortex after testosterone therapy : a pilot study [PDF]
, 2019 Purpose: The importance of the surrounding ovarian stromal cells and extracellular matrix in the development and maturation of follicles has recently gained attention.
De Roo, Chloë +6 more
core +2 more sources