Results 111 to 120 of about 168,582 (335)

FSTL1 Orchestrates Metabolic‐Epigenetic Crosstalk: Glycolysis‐Dependent H3K18 Lactylation Drives Cartilage Fibrosis in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
FSTL1 promotes glycolysis during chondrocyte fibrosis by triggering the HIF‐1 signaling pathway, which causes lactate to accumulate. The buildup of lactate leads to changes in histone lysine lactylation, which in turn enhances the expression of genes associated with fibrosis.
Feng Lu   +12 more
wiley   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

open access: yesAdvanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng   +9 more
wiley   +1 more source

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

open access: yesAdvanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu   +10 more
wiley   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo   +7 more
wiley   +1 more source

Controlled ovarian stimulation in cancer patients under 18 years old; a case series

open access: yesJournal of Ovarian Research
Background Fertility preservation for adolescent pubescent girls is a concern of the healthcare system and parents. Oocyte cryopreservation is regarded as a standard medical intervention for patients with a minimum age of 18 years. Evidence suggests that
Azar Yahyaei   +2 more
doaj   +1 more source

CRYOPRESERVATION OF REPRODUCTIVE PRODUCTS AS AN EFFECTIVE METHOD FOR PRESERVING THE BIODIVERSITY OF STURGEON FISH SPECIES (REVIEW)

open access: yesRibogospodarsʹka Nauka Ukraïni, 2016
Purpose. In recent years, cryopreservation of reproductive products has widely been used as one of the accessible and in some cases the only ways of preserving and supporting the number of endangered fish species including sturgeon fish species ...
I. Kononenko, V. Bekh
doaj   +1 more source

Cryopreservation of Pike Perch Sperm in Hatchery Conditions [PDF]

open access: yes, 2008
Experiments were carried out on pike perch (Sander lucioperca L.) to find a method for stripping sperm without contamination by urine, to determine sperm concentration, and to fertilize large batches of eggs with cryopreserved sperm.
Bokor, Zoltán   +3 more
core  

Five-dimensional imaging of freezing emulsions with solute effects

open access: yes, 2018
The interaction of objects with a moving solidification front is a common feature of many industrial and natural processes such as metal processing, the growth of single-crystals, the cryopreservation of cells, or the formation of sea ice. Solidification
Dedovets, Dmytro   +2 more
core   +3 more sources

Genebank ‐ in vitro propagation of potato and sweetpotato. CIP‐SOP056 V 3.0 [PDF]

open access: yes, 2020
This procedure describes the in vitro multiplication of potato and sweetpotato germplasm for international and national germplasm distribution, as well as, in vitro conservation, phytosanitary, and cryopreservation ...
Anglin, N.L.   +4 more
core  

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