Results 211 to 220 of about 68,611 (312)
Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics
American Journal of Hematology, Volume 101, Issue 7, Page 1632-1649, July 2026.ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan +10 more
wiley +1 more source
Cancer, Volume 132, Issue 13, 1 July 2026.Abstract Adolescents and young adults (AYAs; aged 15–39 years) with cancer face significant threats to future fertility. Despite fertility preservation (FP) guidelines, disparities in access persist, particularly among female AYAs. This systematic review aims to describe FP access and explore disparities by sociodemographic and clinical factors among ...
Marcela Algave +3 more
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.This study investigated the in vitro effects of green tea extract (GTE) and (+)‐catechin on semen quality parameters of Arabi rams during chilled storage. The results showed that GTE and catechin enhance semen parameters during chilled storage, with optimal effects at specific concentrations.
Robab Nabhani +2 more
wiley +1 more source
An Aging Clock Based on Immune Repertoire Features: COVID‐19 Accelerates Aging
Aging Cell, Volume 25, Issue 7, July 2026.We systematically profiled TCR/BCR repertoires in Chinese individuals and paired COVID‐19 samples, revealed aging‐driven remodeling and COVID‐accelerated immune senescence, and built a reliable immune repertoire aging clock for immune senescence evaluation.
Xin Gao +13 more
wiley +1 more source
Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?
Andrology, Volume 14, Issue 5, Page 1272-1281, July 2026.ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto +12 more
wiley +1 more source
Out There No One Has a Right to Die
Bioethics, Volume 40, Issue 6, Page 565-572, July 2026.ABSTRACT The eventual goal of space exploration is to colonize exoplanets and their moons outside our solar system. This is a dangerous and immoral endeavour. The extraterrestrial life forms encountered would be hostile, vulnerable or both, and the descendants of the original pioneers would be involuntarily exposed to hazardous conditions and ...
Matti Häyry
wiley +1 more source
Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies
Clinical Endocrinology, Volume 105, Issue 1, Page 14-21, July 2026.ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley +1 more source
Diagnostic yield of OCT3/4 reflex testing in testicular biopsy
Histopathology, Volume 89, Issue 1, Page 136-143, July 2026.GCNIS detection frequency was 48/3353 (1.4%) testicular biopsies from 42/1870 (2.2%) men who underwent testicular biopsy with or without testicular sperm extraction (TESE). OCT3/4 was particularly helpful for detecting interstitial seminoma, GCNIS coexisting with mature spermatogenesis, and focal GCNIS.
Roselyne Choiniere +2 more
wiley +1 more source
ZEB1 Modifies VE‐Cadherin Signaling in Lymphatic Endothelial Cells
Microcirculation, Volume 33, Issue 5, July 2026.ABSTRACT Objective Zinc finger E‐box‐binding homeobox 1 (ZEB1) is a transcription factor primarily known for its regulatory roles in epithelial‐to‐mesenchymal transition (EMT) and cell fate determination. Recent studies suggest that endothelial ZEB1 signaling promotes blood vessel growth and reduces junctional integrity, although the underlying ...
Nada S. Ahmed +17 more
wiley +1 more source
International Journal of Cancer, Volume 158, Issue 12, Page 3091-3100, 15 June 2026.What's new? Adaptive immune responses are typically limited in pancreatic ductal adenocarcinoma, resulting in minimal efficacy of immune checkpoint inhibitors. Tumor Treating Fields (TTFields) therapy, which uses low‐intensity intermediate‐frequency electric fields to disrupt cancer cell processes, has been approved for certain cancers.
Tal Kan +21 more
wiley +1 more source