Results 71 to 80 of about 108,480 (310)
Advanced Science, EarlyView.In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang +11 more
wiley +1 more source
Designing an optimal cryopreservation protocol for human embryonic stem cells: A systematic approach [PDF]
, 2010 Human embryonic stem cells (hESCs) are derived from the inner cell mass of the human blastocyst. They are pluripotent cells which can differentiate into a wide range of cell types, making them potentially useful for the treatment of diseases such as ...
Olarewaju, Oluseun
core
Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
wiley +1 more source
, 2020 Seeds are one of the preferable and most used sources of germplasm for the ex situ preservation of plant genetic resources. They are generally stored dry at -20 °C in seed banks following international standards.
Rachael M. Davies +5 more
core +1 more source
Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids
Advanced Science, EarlyView.Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan +19 more
wiley +1 more source
Cryopreservation as part of the conservation strategy of Fragaria germplasm in Germany
In Germany, genetic resources of the genus Fragaria are predominantly represented by the 267 strawberry cultivars of the German Fruit Genebank, which is a decentralized network of different stakeholders, and the comprehensive wild species collection of ...
Wöhner, T., Flachowsky, H., Höfer, M.
core +1 more source
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
, 2015 Copyright © 2015 Elsevier Ltd. All rights reserved.Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment..
Mitchell, Rod T +5 more
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Preculture medium optimization for in vitro microcuttings in the cryopreservation prozess of the grapevine cultivar 'Graševina' [PDF]
, 2022 Grapevine (Vitis vinifera L.) is one of the oldest agricultural species. Wide application of this culture in the economy makes it one of the most important agricultural fruit culture in the world.
Stupić, Domagoj +8 more
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Advanced Science, EarlyView.ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon +20 more
wiley +1 more source