Results 71 to 80 of about 33,639 (248)

Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults [PDF]

, 2015
Copyright © 2015 Elsevier Ltd. All rights reserved.Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment..
Mitchell, Rod T, Anderson, Richard A, Spears, Norah, Wallace, W Hamish B, Kelsey, Thomas W, Telfer, Evelyn E   +5 more
core   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation [PDF]

, 2014
Background: Ovarian tissue cryopreservation with later reimplantation has been shown to preserve fertility in adult women, but this approach remains unproven and experimental in children and adolescents.
Edgar, Angela E, Anderson, Richard A, Wallace, W Hamish B, Smith, Alice Grove, Kelsey, Thomas W   +4 more
core   +1 more source

Long-term (35 years) cryopreservation of Echinococcus multilocularis metacestodes [PDF]

, 2020
The metacestode of Echinococcus multilocularis is the etiological agent of alveolar echinococcosis. The metacestode stage used for research is maintained in rodents by serial passages. In order to determine whether cryopreservation of E.
Kronenberg, Philipp A, Alvarez Rojas, Cristian A; https://orcid.org/, Alvarez Rojas, Cristian A, Laurimäe, Teivi, Deplazes, Peter, Laurimäe, Teivi; https://orcid.org/, Ramp, Theodor W, Eckert, Johannes   +7 more
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Cryopreservation as part of the conservation strategy of Fragaria germplasm in Germany

In Germany, genetic resources of the genus Fragaria are predominantly represented by the 267 strawberry cultivars of the German Fruit Genebank, which is a decentralized network of different stakeholders, and the comprehensive wild species collection of ...
Wöhner, T., Flachowsky, H., Höfer, M.
core   +1 more source

Bio‐Inspired Oligocellulose‐Regulated Ice‐Water Interfaces Enable Sustained Ion Transport in Frozen Aqueous Zinc Batteries

Advanced Science, EarlyView.
Inspired by antifreeze glycoproteins (AFGPs), we synthesized a type of oligomeric cellulose (OC‐8) to inhibit ice formation and enlarge the inter‐ice water channel for transportation. Typical confocal fluorescence experiments display the expansion of the ice‐water interface for zinc‐ion transport.
Zeyu Zhu, Jingxuan Pan, Haoran Ma, Boya Yuan, Cristina Carucci, Sunghak Park, Chong Gao, Minmin Liang, Kaiqi Li, Wei Li, Dan Wang, Xiaoting Chen, Zhiyuan He   +12 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Polyproline: A Synthetic Polypeptide With Unique Properties

Angewandte Chemie, EarlyView.
Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec, Josué M. Galindo, Colin Bonduelle, Andreas Heise   +3 more
wiley   +2 more sources

Hydrogel microcapsulation technology reduces the DMSO concentration required for stem cell cryopreservation

Regenerative Therapy
Introduction: Stem cell therapy is increasingly advancing towards clinical applications, with cryopreservation playing a critical role in cell transplantation.
Zhongqin Tang, Ying Wang, Ziling Yang, Juan Chen, Shuqi Cai, Zhiguo Zhang, Jianye Wang, Zhaolian Wei   +7 more
doaj   +1 more source