Targeting oncogenic mutations in colorectal cancer using cryptotanshinone
PLOS ONE, 2020 Colorectal cancer (CRC) is one of the most prevalent types of cancer in the world and ranks second in cancer deaths in the US. Despite the recent improvements in screening and treatment, the number of deaths associated with CRC is still very significant.
Haswanth Vundavilli +5 more
openaire +4 more sources
Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro [PDF]
Experimental & Molecular Medicine, 2005 In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity.
Jong Moon, Hur +3 more
openaire +2 more sources
Nitrogen Fertilization Improves Growth and Bioactive Compound Content for Salvia miltiorrhiza Bunge
Horticulturae, 2023 Salvia miltiorrhiza B., an herb used in traditional Chinese medicine, has been widely used to prevent and treat cardiovascular and other diseases. Currently, the majority of medicinal plants used in the US are imported from foreign countries, which ...
Zhiheng Xing +4 more
doaj +1 more source
Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes [PDF]
Pharmaceutical Biology, 2015 The serious side effect of Adriamycin (ADR) is cardiomyopathy. Cryptotanshinone (CRY) is widely and safely used as antioxidant with MTD more than 5 mg/g in rats (p.o).The objective of this study is to study the protection effects of CRY against ADR-induced mitochondrial dysfunction in cardiomyocytes.The chemical administration lasted for 20 days with ...
Yanshan, Zhang +6 more
openaire +2 more sources
In Silico investigation of Danshen (Salvia miltiorrhiza) derivatives as potential inhibitor of amyloid beta fibril and design of promising lead compounds as Anti Alzheimer’s drug by pharmacophore modeling [PDF]
Alzheimers DementAbstract Background Danshen (Salvia miltiorrhiza) is a kind of rhizome and traditionally being used for the long time in China. In recent years some exceptional experimental works have been done on Danshen derivatives and evidence have been found that several Danshen derivatives are able to inhibit amyloid beta fibril, a pathological hallmark of ...
Saran L.
europepmc +2 more sources
Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
, 2014 published_or_final_versio
CHEUNG, F +7 more
core +10 more sources
Frontiers in Pharmacology, 2021 Among cancers, colorectal cancer (CRC) has one of the highest annual incidence and death rates. Considering severe adverse reactions associated with classical chemotherapy medications, traditional Chinese medicines have become potential drug candidates ...
Xiaojing Fu +5 more
doaj +1 more source
Horticulturae, 2023 Salvia miltiorrhiza Bunge (danshen) is a traditional herbal medicine and has been widely used to prevent and treat cardiovascular and other diseases. Currently, the majority of medicinal plants, including danshen, used in the United States are imported ...
Zhiheng Xing +4 more
doaj +1 more source
Development and application of base editing systems in Salvia miltiorrhiza for precise metabolic engineering. [PDF]
Plant Biotechnol JPlant Biotechnology Journal, Volume 23, Issue 12, Page 5619-5621, December 2025.
Yao Q +10 more
europepmc +2 more sources
Frontiers in Pharmacology, 2023 Introduction: Cryptotanshinone(CTS), a compound derived from the root of Salvia miltiorrhiza, has been linked to various of diseases, particularly pulmonary fibrosis.
Xiangjun He +6 more
doaj +1 more source