Results 51 to 60 of about 860,806 (269)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Growth of High-Quality CLBO Crystals for High-Power 266 nm DUV Laser

Crystals
In this work, LiF was introduced as a flux additive to overcome the high viscosity challenge of the self-flux system, which successfully grew a large-scale cesium lithium borate (CLBO) single crystal with dimensions of 136 × 132 × 68 mm3 and a weight of ...
Jinguo Wang, Lei Yang, Gang He, Zhanggui Hu   +3 more
doaj   +1 more source

Characterization of LuGdVO3 mixed crystal prepared by one new method

Results in Physics, 2019
LuGdVO3 was obtained by annealing the LuGdVO4 crystal at 1500 °C under vacuum condition. The X-ray fluorescence analysis method was used to measure the concentrations of Lu and Gd elements in LuGdVO4.
Nianjing Ji, Yang Chen, Ziqing Li, Jiyang Wang, Xiulan Duan, Huaidong Jiang   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Branch-Chain-Rich Diisopropyl Ether with Steric Hindrance Facilitates Stable Cycling of Lithium Batteries at − 20 °C

Nano-Micro Letters
Highlights Branch chain-rich diisopropyl ether (DIPE) was selected as co-solvent of low-temperature electrolyte for lithium metal battery. The introduction of DIPE improved the disorder of electrolyte and the branch chains from DIPE exclude other ...
Houzhen Li, Yongchao Kang, Wangran Wei, Chuncheng Yan, Xinrui Ma, Hao Chen, Yuanhua Sang, Hong Liu, Shuhua Wang   +8 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Secondary cold isostatic pressing-assisted pressureless sintering of high-density h-BN ceramics

Journal of Advanced Ceramics
Owing to its strong B–N covalent bonds and inferior dissolution–precipitation characteristics in selected liquid phases, densification of h-BN ceramics is generally achieved via pressure-assisted sintering techniques.
Shuxuan Wang, Yuqi Yang, Lei Yang, Xiaodong Li, Jiakai Cao, Gang He   +5 more
doaj   +1 more source