Results 71 to 80 of about 833,453 (290)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Controlled Synthesis and Properties of 3d–4f Metals Co-doped Polyoxometalates-Based Materials

Nanoscale Research Letters, 2020
It is challenging to explore and prepare polyoxometalates-based nanomaterials (PNMs) with controllable morphologies and diversiform components. Herein, 3d–4f metals are introduced into isopolyoxometalates and Anderson-type polyoxometalates, CeCdW12 ...
Ning Liu, Ningning Guo, Lin Sun, Shixian Liu, Guan Wang, Yuan Zhao   +5 more
doaj   +1 more source

Nonclassical 2-photon interference with separate intrinsically narrowband fibre sources

, 2009
In this paper, we demonstrate a source of photon pairs based on four-wave-mixing in photonic crystal fibres. Careful engineering of the phase matching conditions in the fibres enables us to create photon pairs at 597 nm and 860 nm in an intrinsically ...
A. Clark, Alibart, B. Cemlyn, Burnham, C. Xiong, Fan, Fulconis, Garay-Palmett, Giacobino, Grice, Hofmann, Hong, J. Fulconis, J. G. Rarity, Knill, M. Halder, Mosley, Nagata, Soujaeff, Stevenson, Thompson, W. J. Wadsworth, Wang, Xiong   +23 more
core   +1 more source

Halogen Bonding in Crystal Engineering [PDF]

Acta Crystallographica Section A Foundations of Crystallography, 2005
The term halogen bonding encompasses any non-covalent interaction involving halogens as electrophilic species. High strength and directionality are the remarkable features of halogen bonding that fully justify its use as a primary intermolecular interaction to dictate molecular self-assembly processes.
METRANGOLO, PIERANGELO, T. Pilati, RESNATI, GIUSEPPE, URSINI, MAURIZIO   +3 more
openaire   +8 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Induced fit growth of Ga-based semiconductor thin films for brain-inspired electronics and optoelectronics

Light: Science & Applications
Current crystalline thin-film production techniques typically require specific growth substrates, posing significant challenges for their use in flexible electronics and integrated optoelectronics.
Zixu Sa, Kepeng Song, You Meng, Wenfeng Wu, Zhaocong Wang, Pengsheng Li, Jie Zhang, Zeqi Zang, Guangcan Wang, Mingxu Wang, Zhitai Jia, Yang Tan, Weifeng Li, SenPo Yip, Feng Chen, Johnny C. Ho, Zai-xing Yang   +16 more
doaj   +1 more source

Author Correction: Liquid crystal elastomer coatings with programmed response of surface profile

Nature Communications, 2018
The original version of this Article contained errors in Figs. 1a, 2a, 3a, and 4b, in which the units on the scale bars incorrectly read ‘µm’ rather than the correct ‘nm.’ This has been corrected in both the PDF and HTML versions of the Article.
Greta Babakhanova, Taras Turiv, Yubing Guo, Matthew Hendrikx, Qi-Huo Wei, Albert P. H. J. Schenning, Dirk J. Broer, Oleg D. Lavrentovich   +7 more
doaj   +1 more source

Revealing the chirality origin and homochirality crystallization of Ag14 nanocluster at the molecular level

Nature Communications, 2021
The preparation of chiral monolayer-protected metal clusters is interesting for their potential applications in a variety of fields, including catalysis.
Xiao-Qian Liang, Ying-Zhou Li, Zhi Wang, Shan-Shan Zhang, Yi-Cheng Liu, Zhao-Zhen Cao, Lei Feng, Zhi-Yong Gao, Qing-Wang Xue, Chen-Ho Tung, Di Sun   +10 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source