Results 41 to 50 of about 154,550 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Failure Mechanism of Tip-Trailing-Edge Fracture in a Thin-Walled Single-Crystal Turbine Blade: An Uncertainty-Based Vibration Analysis

Machines
To resolve the fatigue fracture occurring at the tip trailing edge of thin-walled single-crystal turbine rotor blades for a specific aero-engine, this paper derives the relationship between the single-crystal constitutive stiffness matrix and crystal ...
Wenting Jiang, Di Liu, Lilun Geng, Yizhou Long, Wanchao Sun, Yinli Feng, Enliang Huang   +6 more
doaj   +1 more source

Modelling of crystal plasticity effects on the crack initiation energies of a bi-crystal interface (Nb/ A120 3)

Computer Assisted Methods in Engineering and Science, 2022
The present paper examines the crystal orientation effects on the energy at the crack-tip of niobium/ alumina joints. The analyses have been done using crystal plasticity theory.
Amir Siddiq, Siegfried Schmauder
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

LOW CYCLE FATIGUE LIFE PREDICTION METHOD FOR SINGLE CRYSTAL NICKEL-BASE SUPERALLOYS AT HIGH TEMPERATURE

Jixie qiangdu, 2015
A low cycle fatigue life prediction method for single crystal nickel-base superalloys at high temperature is presented,and the method can consider the effect of average stress,strain ratio and crystal orientation on fatigue life.Firstly,a fatigue life ...
CHEN Hong, JIANG HongDe
doaj  

The preferred orientation of electrodeposited dendrites of lead, tin and zinc

Journal of Electrochemical Science and Engineering
Morphology and crystal orientation of electrolytically produced dendrites of lead, tin, and zinc have been investigated with the aim of establishing any correlation between them.
Nebojša D. Nikolić, Jelena Lović, Vesna Maksimović, Nikola Vuković, Predrag Živković   +4 more
doaj   +1 more source

Cooperative control of perpendicular magnetic anisotropy via crystal structure and orientation in freestanding SrRuO3 membranes

npj Flexible Electronics, 2022
Flexible magnetic materials with robust and controllable perpendicular magnetic anisotropy (PMA) are highly desirable for developing flexible high-performance spintronic devices. However, it is still challenge to fabricate PMA films on polymers directly.
Zengxing Lu, Yongjie Yang, Lijie Wen, Jiatai Feng, Bin Lao, Xuan Zheng, Sheng Li, Kenan Zhao, Bingshan Cao, Zeliang Ren, Dongsheng Song, Haifeng Du, Yuanyuan Guo, Zhicheng Zhong, Xianfeng Hao, Zhiming Wang, Run-Wei Li   +16 more
doaj   +1 more source