Results 61 to 70 of about 485,962 (354)

Dioxygen, an unexpected carbonic anhydrase ligand

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, grouped into seven different classes, which catalyze the reaction of CO2 hydration to bicarbonate and protons.
Marta Ferraroni, Roberto Gaspari, Andrea Scozzafava, Andrea Cavalli, Claudiu T. Supuran   +4 more
doaj   +1 more source

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

eLife, 2016
HLA class I presentation of pathogen-derived peptide ligands is essential for CD8+ T-cell recognition of Toxoplasma gondii infected cells. Currently, little data exist pertaining to peptides that are presented after T. gondii infection.
Curtis McMurtrey, Thomas Trolle, Tiffany Sansom, Soumya G Remesh, Thomas Kaever, Wilfried Bardet, Kenneth Jackson, Rima McLeod, Alessandro Sette, Morten Nielsen, Dirk M Zajonc, Ira J Blader, Bjoern Peters, William Hildebrand   +13 more
doaj   +1 more source

Influence of Terminal Functionality on the Crystal Packing Behaviour and Cytotoxicity of Aromatic Oligoamides

Frontiers in Chemistry, 2021
The synthesis and characterization of three aromatic oligoamides, constructed from the same pyridyl carboxamide core but incorporating distinct end groups of acetyl (Ac) 1, tert-butyloxycarbonyl (Boc) 2 and amine 3 is reported.
Pierre Delfosse, Colin C. Seaton, Louise Male, Rianne M. Lord, Rianne M. Lord, Sarah J. Pike, Sarah J. Pike   +6 more
doaj   +1 more source

Spikes in Cosmic Crystallography

, 2002
If the universe is multiply connected and small the sky shows multiple images of cosmic objects, correlated by the covering group of the 3-manifold used to model it.
A. BERNUI, A. F. F. TEIXEIRA, G. I. GOMERO, Gomero G. I., Lehoucq R., Lehoucq R., M. J. REBOUÇCAS, Zeldovich Ya. B.   +7 more
core   +1 more source

Structure of catalase determined by MicroED. [PDF]

, 2014
MicroED is a recently developed method that uses electron diffraction for structure determination from very small three-dimensional crystals of biological material.
Gonen, Tamir, Hattne, Johan, Nannenga, Brent L, Reyes, Francis E, Shi, Dan   +4 more
core   +1 more source

MX2: a high-flux undulator microfocus beamline serving both the chemical and macromolecular crystallography communities at the Australian Synchrotron

Journal of Synchrotron Radiation, 2018
A microfocus macromolecular crystallography beamline at the Australian Synchrotron is presented.
D. Aragão, J. Aishima, Hima Cherukuvada, R. Clarken, M. Clift, N. Cowieson, D. Ericsson, C. Gee, Sofia Macedo, Nathan Mudie, S. Panjikar, J. Price, A. Riboldi-Tunnicliffe, Robert Rostan, R. Williamson, T. Caradoc-Davies   +15 more
semanticscholar   +1 more source

Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing

Bioinorganic Chemistry and Applications
Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with cognitive decline and loss of memory. It is postulated that the generation of reactive oxygen species (ROS) in Fenton-like reaction connected with Cu(II)/Cu(I) redox ...
Marianna Flora Tomasello, Maria Carmela Di Rosa, Irina Naletova, Michele Francesco Maria Sciacca, Alessandro Giuffrida, Giuseppe Maccarrone, Francesco Attanasio   +6 more
doaj   +1 more source

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

eLife, 2018
VRC01 broadly neutralizing antibodies (bnAbs) target the CD4-binding site (CD4BS) of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein (Env). Unlike mature antibodies, corresponding VRC01 germline precursors poorly bind to Env.
Andrew J Borst, Connor E Weidle, Matthew D Gray, Brandon Frenz, Joost Snijder, M Gordon Joyce, Ivelin S Georgiev, Guillaume BE Stewart-Jones, Peter D Kwong, Andrew T McGuire, Frank DiMaio, Leonidas Stamatatos, Marie Pancera, David Veesler   +13 more
doaj   +1 more source

4D ultrafast electron diffraction, crystallography, and microscopy [PDF]

, 2006
In this review, we highlight the progress made in the development of 4D ultrafast electron diffraction (UED), crystallography (UEC), and microscopy (UEM) with a focus on concepts, methodologies, and prototypical applications.
Zewail, Ahmed H.
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source