Results 11 to 20 of about 534 (117)

Self-Assembling Nanovaccine Enhances Protective Efficacy Against CSFV in Pigs [PDF]

Frontiers in Immunology, 2021
Classical swine fever virus (CSFV) is a highly contagious pathogen, which pose continuous threat to the swine industry. Though most attenuated vaccines are effective, they fail to serologically distinguish between infected and vaccinated animals, hindering CSFV eradication.
Ze-Hui Liu, Hui-Ling Xu, Guang-Wei Han, Li-Na Tao, Ying Lu, Su-Ya Zheng, Wei-Huan Fang, Wei-Huan Fang, Fang He, Fang He   +9 more
openaire   +3 more sources

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protect Pigs against a Virulent CSFV Challenge

Viruses, 2023
Classical swine fever (CSF) remains one of the most economically significant viral diseases affecting domestic pigs and wild boars worldwide. To develop a safe and effective vaccine against CSF, we have constructed a triple gene-deleted pseudorabies virus (PRVtmv)-vectored bivalent subunit vaccine against porcine circovirus type 2b (PCV2b) and CSFV ...
Ediane Silva, Elizabeth Medina-Ramirez, Selvaraj Pavulraj, Douglas P. Gladue, Manuel Borca, Shafiqul I. Chowdhury   +5 more
openaire   +3 more sources

Lactate facilitates classical swine fever virus replication by enhancing cholesterol biosynthesis

iScience, 2022
Summary: An emerging topic in virology is that viral replication is closely linked with the metabolic reprogramming of host cells. Understanding the effects of reprogramming host cell metabolism due to classical swine fever virus (CSFV) infection and the
Xiaodong Zou, Yang Yang, Feng Lin, Jiahuan Chen, Huanyu Zhang, Linquan Li, Hongsheng Ouyang, Daxin Pang, Linzhu Ren, Xiaochun Tang   +9 more
doaj   +1 more source

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protects Pigs against PCV2b Challenge and Induces Serum Neutralizing Antibody Response against CSFV [PDF]

Vaccines, 2022
Porcine circovirus type 2 (PCV2) is endemic worldwide. PCV2 causes immunosuppressive infection. Co-infection of pigs with other swine viruses, such as pseudorabies virus (PRV) and classical swine fever virus (CSFV), have fatal outcomes, causing the swine industry significant economic losses in many if not all pig-producing countries.
Selvaraj Pavulraj, Katrin Pannhorst, Rhett W. Stout, Daniel B. Paulsen, Mariano Carossino, Denise Meyer, Paul Becher, Shafiqul I. Chowdhury   +7 more
openaire   +3 more sources

Antiviral activity of ISG15 against classical swine fever virus replication in porcine alveolar macrophages via inhibition of autophagy by ISGylating BECN1

Veterinary Research, 2020
Interferons (IFNs) induce the expression of interferon-stimulated genes (ISGs) for defense against numerous viral infections, including classical swine fever virus (CSFV). However, the mechanisms underlying the effect of ISGs on CSFV infection are rarely
Cheng Li, Yifan Wang, Hongqing Zheng, Wang Dong, Huifang Lv, Jihui Lin, Kangkang Guo, Yanming Zhang   +7 more
doaj   +1 more source

MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells

Emerging Microbes and Infections, 2020
Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the Flaviviridae family. To date, the host factors required for CSFV entry remain poorly characterized.
Guanglai Zheng, Lian-Feng Li, Yuexiu Zhang, Liang Qu, Wenjing Wang, Miao Li, Shaoxiong Yu, Mo Zhou, Yuzi Luo, Yuan Sun, Muhammad Munir, Su Li, Hua-Ji Qiu   +12 more
doaj   +1 more source

Transcriptome analysis of PK-15 cells expressing CSFV NS4A

BMC Veterinary Research, 2022
Abstract Background Classical swine fever (CSF) is a severe disease of pigs that results in huge economic losses worldwide and is caused by classical swine fever virus (CSFV). CSFV nonstructural protein 4 A (NS4A) plays a crucial role in infectious CSFV particle formation.
Huifang Lv, Zhifeng Peng, Bingxin Jia, Huiyuan Jing, Sufang Cao, Zhikun Xu, Wang Dong   +6 more
openaire   +3 more sources

Adverse Effects of Classical Swine Fever Virus LOM Vaccine and Jeju LOM Strains in Pregnant Sows and Specific Pathogen-Free Pigs

Pathogens, 2019
In Jeju island of South Korea, a classical swine fever (CSF) non-vaccinated region, many pig farmers insisted on abortion and stillbirth in pregnant sows and high mortality of suckling/weaning piglets by circulating CSF virus from 2014 to 2018.
SeEun Choe, Jae-Hoon Kim, Ki-Sun Kim, Sok Song, Ra Mi Cha, Wan-Choul Kang, Hyeun-Ju Kim, Gyu-Nam Park, Jihye Shin, Hyoung-Nam Jo, In-Soo Cho, Bang-Hun Hyun, Bong-Kyun Park, Dong-Jun An   +13 more
doaj   +1 more source

Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus

Viruses, 2023
Classical swine fever virus (CSFV), which is a positive-sense, single-stranded RNA virus with an envelope, is a member of the Pestivirus genus in the Flaviviridae family.
Xin Guo, Maolin Zhang, Xiaomin Liu, Yannan Zhang, Chongyang Wang, Yidi Guo   +5 more
doaj   +1 more source

LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection [PDF]

Autophagy, 2020
Cellular metabolism caters to the energy and metabolite needs of cells. Although the role of the terminal metabolic enzyme LDHB (lactate dehydrogenase B) in the glycolysis pathway has been widely studied in cancer cells, its role in viral infection is relatively unknown.
Shuangqi, Fan, Keke, Wu, Mingqiu, Zhao, Jin, Yuan, Shengming, Ma, Erpeng, Zhu, Yuming, Chen, Hongxing, Ding, Lin, Yi, Jinding, Chen   +9 more
openaire   +2 more sources