Results 61 to 70 of about 534 (117)

Interaction of SERINC5 and IFITM1/2/3 regulates the autophagy-apoptosis-immune network under CSFV infection

Virulence, 2022
The host restriction factor serine incorporator 5 (SERINC5) plays a key role in inhibiting viral activity and has been shown to inhibit classical swine fever virus (CSFV) infection. However, the action of SERINC5 in the interaction between host cells and
Wenhui Li, Zilin Zhang, Liangliang Zhang, Qingfeng Zhou, Yuwan Li, Lin Yi, Hongxing Ding, Mingqiu Zhao, Jinding Chen, Shuangqi Fan   +9 more
doaj   +1 more source

LDHA-lactate axis modulates mitophagy inhibiting CSFV replication

Journal of Virology
ABSTRACT Lactate dehydrogenase A (LDHA) plays a crucial role in regulating lactate synthesis in various biological processes. Lactate, a byproduct of glycometabolism, has been recognized as a unique molecule with implications in both metabolism and immunity.
Sen Zeng, Zipeng Luo, Wenhui Zhu, Zhanhui Zhang, Ruibo Zhao, Shuaiqi Zhu, Qi Qiu, Nan Cao, Xinliang Fu, Wenjun Liu, Shuangqi Fan, Cheng Fu   +11 more
openaire   +2 more sources

CSFV protein NS5A activates the unfolded protein response to promote viral replication

Virology, 2020
Classical swine fever is a world organization for animal health listed disease and is caused by classical swine fever virus (CSFV). CSFV can induced unfolded protein response (UPR) and whether NS5A protein plays a role in this process remains unknown.
Zhang, Chengcheng, Zhao, Fuxi, Guo, Mengjiao, Ruan, Baoyang, Wang, Xuefeng, Wu, Yantao, Zhang, Xiaorong   +6 more
openaire   +2 more sources

Research Progress Based on SpyTag/SpyCatcher Self‐Assembling Peptides and Their Applications in the Food Field

Food Bioengineering, Volume 4, Issue 3, Page 279-291, September 2025.
The formation of isopeptide bonds in the SpyTag/SpyCatcher system and its application in the food field ABSTRACT The SpyTag/SpyCatcher system is a modular protein assembly tool based on isopeptide bond‐mediated covalent conjugation, distinguished by mild reaction conditions, rapid ligation rate, and independence from exogenous enzymes or chemical ...
Meng‐meng Cai, Zi‐fu Ni, Zhong‐ke Sun, Xiao‐long Li, Zi‐hao Wang, Min Zhang, Cheng‐wei Li   +6 more
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, Volume 5, Issue 4, August 2025.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Short communication: Stability and integrity of classical swine fever virus RNA stored at room temperature

Spanish Journal of Agricultural Research, 2017
Worldwide cooperation between laboratories working with classical swine fever virus (CSFV) requires exchange of virus isolates. For this purpose, shipment of CSFV RNA is a safe alternative to the exchange of infectious material.
Damarys Relova, Lester J. Pérez, Liliam Ríos, Liani Coronado, Yoandry Hinojosa, Ana M. Acevedo, María T. Frías, Carmen L. Perera   +7 more
doaj   +1 more source

Immunomodulatory effect of swine CCL20 chemokine in DNA vaccination against CSFV

Veterinary Immunology and Immunopathology, 2011
The objective of this work was to explore whether a plasmid expressing CCL20 chemokine could improve the immune response against CSFV in co-administration with a DNA vaccine expressing the E2 protein. The immunization of pigs with the DNA vaccine formulation, that contains swine CCL20 chemokine, resulted in the homogenous induction of detectable levels
Tarradas, J., Álvarez, B., Fraile, L., Rosell, R., Muñoz, M., Galindo-Cardiel, I., Domingo, M., Dominguez, J., Ezquerra, A., Sobrino, F., Ganges, L.   +10 more
openaire   +3 more sources

CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication [PDF]

Frontiers in Microbiology, 2017
Classical swine fever (CSF) is an OIE-listed, highly contagious animal disease caused by classical swine fever virus (CSFV). The endoplasmic reticulum (ER) is an organelle in which the replication of many RNA viruses takes place. During viral infection, a series of events elicited in cells can destroy the ER homeostasis that cause ER stress and induce ...
Wencheng He, Hailuan Xu, Hongchao Gou, Jin Yuan, Jiedan Liao, Yuming Chen, Shuangqi Fan, Baoming Xie, Shaofeng Deng, Yangyi Zhang, Jinding Chen, Mingqiu Zhao   +11 more
openaire   +3 more sources

Advancing ORFV‐Based Therapeutics to the Clinical Stage

Reviews in Medical Virology, Volume 35, Issue 3, May 2025.
ABSTRACT The Orf virus (ORFV) is the prototype member of the parapoxvirus family and has long been recognized for its robust immunogenicity, favourable safety profile and its ability to stimulate both cellular and humoural immune responses without inducing significant anti‐vector immunity.
Matthias Helmold, Ralf Amann
wiley   +1 more source

Research review on non-structural protein 3 (ns3) of classical swine fever virus and its potential applications in vaccine development [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi
Classical Swine Fever Virus (CSFV) is a virus that poses a serious threat to the pig farming industry, and its non-structural protein 3 (NS3) plays a key role in the virus"s replication, pathogenicity, and immune evasion.
Hai-Yang YU, Dong-Mei GAO, Jun ZHAO
doaj   +1 more source