Results 91 to 100 of about 281,124 (345)

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

open access: yesAdvanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang   +10 more
wiley   +1 more source

Defect Detection for Enhanced Traceability in Naval Construction

open access: yesSensors
The digitalization of shipbuilding processes has become an important trend in modern naval construction, enabling more efficient design, assembly, and maintenance operations. A key aspect of this digital transformation is traceability, which ensures that
Paula Arcano-Bea   +5 more
doaj   +1 more source

TESTES DE DETERMINAÇÃO DE PERDAS INVISÍVEIS E EFICIÊNCIA DE LIMPEZA EM COLHEITA DE CANA-DE-AÇÚCAR COM E SEM PALHA

open access: yesRevista Brasileira de Engenharia de Biossistemas, 2007
No Brasil, a agroindústria canavieira processou 431,4 milhões de toneladas de cana-de-açúcar na safra de 2005/2006. Atualmente de 5 a 15% desta matéria-prima é perdida no campo, quando o corte é feito de forma manual ou mecanizada respectivamente. A lei
JORGE LUIS MANGOLINE NEVES   +3 more
doaj   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

open access: yesAdvanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang   +7 more
wiley   +1 more source

Comparative evaluation of the impact of processing methods in determining the levels of health promoting chemical constituents and quality of green tea

open access: yesBeverage Plant Research
The first step of green tea manufacture involves enzyme deactivation by heat application. The present study investigated the effects of various fixing and processing methods viz. steam-roasting (S-6), pan-firing (P-8), blanching (B-2), and CTC cuts after
Biplab Adhikary   +5 more
doaj   +1 more source

Advances in All-Neural Speech Recognition

open access: yes, 2017
This paper advances the design of CTC-based all-neural (or end-to-end) speech recognizers. We propose a novel symbol inventory, and a novel iterated-CTC method in which a second system is used to transform a noisy initial output into a cleaner version ...
Droppo, J.   +3 more
core   +1 more source

CTC Meeting 2020

open access: yes, 2020
Andrej Paška, Radosław Walkowiak, Peter Danko, Marek Nowicki; Nature education, challenges and prospects for tutors.
openaire   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

open access: yesAdvanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song   +4 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

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