Results 81 to 90 of about 281,124 (345)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

PB2431: OUTCOME OF HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR SEVERE APLASTIC ANEMIA IN PEDIATRIC POPULATION - A SINGLE CENTER EXPERIENCE FROM PUBLIC HOSPITAL

HemaSphere, 2023
Rajesh Patil, Ratna Sharma, Pranoti Kini, Amit Jain, Ashutosh Walawalkar, Krunal Shah, Poulami Das, Kalyani Patil, Nidhi Mehta, Santosh Khude, Mamta Manglani   +10 more
doaj   +1 more source

Can closed timelike curves or nonlinear quantum mechanics improve quantum state discrimination or help solve hard problems?

, 2009
We study the power of closed timelike curves (CTCs) and other nonlinear extensions of quantum mechanics for distinguishing nonorthogonal states and speeding up hard computations. If a CTC-assisted computer is presented with a labeled mixture of states to
Charles H. Bennett, Debbie Leung, Graeme Smith, John A. Smolin, S. Aaronson   +4 more
core   +1 more source

CTCs Could Guide Cancer Therapy [PDF]

Cancer Discovery, 2014
Abstract Using a microchip device, scientists were able to capture and culture circulating tumor cells for genetic analysis and drug testing, which identified new tumor mutations that were susceptible to targeted agents.
openaire   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Comparison of Decoding Strategies for CTC Acoustic Models

, 2017
Connectionist Temporal Classification has recently attracted a lot of interest as it offers an elegant approach to building acoustic models (AMs) for speech recognition.
Metze, Florian, Niehues, Jan, Sanabria, Ramon, Sperber, Matthias, Stüker, Sebastian, Waibel, Alex, Zenkel, Thomas   +6 more
core   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Clinical and angiographic profiles and six months outcomes of smokers with acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary angioplasty

Indian Heart Journal, 2018
Background: Outcomes of primary percutaneous coronary intervention (PCI) for acute STEMI (ST-segment elevation myocardial infarction) in smokers are expected to be better than non-smokers as for patients of acute STEMI with or without fibrinolytic ...
A. Gupta, S.K. Verma, R. Sharma, N. Parakh, S. Ramakrishnan, A. Roy, S. Singh, G. Sharma, G. Karthikeyan, N. Naik, R. Yadav, S. Mishra, S. Seth, R. Narang, K.C. Goswami, B. Bhargava, V.K. Bahl   +16 more
doaj   +1 more source

Is Time Travel Too Strange to Be Possible? Determinism and Indeterminism on Closed Timelike Curves

, 2017
Notoriously, the Einstein equations of general relativity have solutions in which closed timelike curves (CTCs) occur. On these curves time loops back onto itself, which has exotic consequences.
Brown, André EX, Ch'ng, Quee-Lim, Currie, Michael, Grundy, Laura J, Hokanson, Jim, Javer, Avelino, Kerr, Rex, Lee, Chee Wai, Li, Chris, Li, Kezhi, Schafer, William R, Yemini, Eviatar   +11 more
core   +2 more sources