Results 111 to 120 of about 47,434 (363)

Profiling lung adenocarcinoma by liquid biopsy: can one size fit all? [PDF]

, 2016
BACKGROUND: Cancer is first and foremost a disease of the genome. Specific genetic signatures within a tumour are prognostic of disease outcome, reflect subclonal architecture and intratumour heterogeneity, inform treatment choices and predict the ...
Cassidy, Amy P, Cassidy, John W, Clifford, Harry W, Hewage, Emil, O'Neill, Hannah L, Patel, Nirmesh, Seres, Bianka, Tsai, Evaline S, Vaughn, Courtney   +8 more
core   +2 more sources

Personalized ctDNA for Monitoring Disease Status in Head and Neck Squamous Cell Carcinoma

Clinical Cancer Research
Purpose: Many patients with locoregionally advanced human papillomavirus–negative head and neck squamous cell carcinoma (HNSCC) relapse. ctDNA has the potential to identify minimal residual disease, but its clinical utility for virus-negative HNSCC is ...
Glenn J Hanna, M. J. Dennis, N. Scarfo, Michelle S Mullin, Rosh K V Sethi, K. Sehgal, D. Annino, L. Goguen, R. Haddad, R. Tishler, D. Margalit, R. Uppaluri, Jonathan D. Schoenfeld, Eleni M. Rettig   +13 more
semanticscholar   +1 more source

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

Advanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou, Jinling Jiang, Liting Guo, Wenqi Xi, Junwei Wu, Qu Cai, Jun Ji, Feng Qi, Jun Zhang   +8 more
wiley   +1 more source

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies

Journal of the Anus, Rectum and Colon
Background: Spatial and temporal heterogeneities of RAS and other molecular genes should be considered in the treatment of metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs ...
Kozo Kataoka, Takeshi Yamada, Manabu Shiozawa, Naoto Takase, Kazuma Ito, Kentaro Yamazaki, Jun Watanabe, Toshihiro Kudo, Takeshi Suto, Toshihiko Matsumoto, Kohei Murata, Yusuke Suwa, Shogen Boku, Hisateru Yasui, Nobuhisa Matsuhashi, Atsuyuki Maeda, Kiichi Sugimoto, Yusuke Matsumoto, Mitsuru Yokota, Johannes Fredebohm, Keita Mori, Masataka Ikeda   +21 more
doaj   +1 more source

Circulating tumor DNA predicts survival in patients with resected high risk stage II/III melanoma [PDF]

, 2017
Background: Patients with high-risk stage II/III resected melanoma commonly develop distant metastases. At present, we cannot differentiate between patients who will recur or those who are cured by surgery.
Corrie, P. G., Dhomen, N., Dunn, Janet A., Fisher, N., Gremel, G., Lee, R. J., Lorigan, P., Marais, R., Marshall, A. (Andrea)‏, Middleton, M. R., Myers, K. A.   +10 more
core   +1 more source

Association of personalized and tumor-informed ctDNA with patient survival outcomes in pancreatic adenocarcinoma

The Oncologist
Introduction Personalized and tumor-informed circulating tumor DNA (ctDNA) testing is feasible and allows for molecular residual disease (MRD) identification in patients with pancreatic ductal adenocarcinoma (PDAC). Methods In this retrospective analysis
G. Botta, M. Abdelrahim, Ronald L. Drengler, Vasily N. Aushev, A. Esmail, G. Laliotis, Chris M. Brewer, Giby V. George, Steven M Abbate, S. Chandana, M. Tejani, Midhun Malla, Dhruv Bansal, S. Rivero-Hinojosa, E. Spickard, Nicole McCormick, M. Cecchini, Jill Lacy, Naomi H. Fei, P. Kasi, A. Kasi, F. Dayyani, Diana L. Hanna, Shruti Sharma, M. Malhotra, A. Aleshin, Minetta C. Liu, A. Jurdi   +27 more
semanticscholar   +1 more source

Making the Rounds: Exploring the Role of Circulating Tumor DNA (ctDNA) in Non-Small Cell Lung Cancer

International Journal of Molecular Sciences, 2022
Advancements in the clinical practice of non-small cell lung cancer (NSCLC) are shifting treatment paradigms towards increasingly personalized approaches.
M. Shields, Kevin Chen, Giselle Dutcher, Ishika Patel, B. Pellini   +4 more
semanticscholar   +1 more source

Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R

Advanced Science, EarlyView.
The TIDE‐Cas14a system, an integrated RPA‐T7‐CRISPR/Cas14a cascade platform incorporating engineered crRNA mismatches, enables ultrasensitive detection of the PIK3CA H1047R mutation in breast cancer circulating tumor DNA, with a limit of detection as low as 0.01%, surpassing the sensitivity of droplet digital PCR.
Yuanyuan Yu, Mengru Jin, Weiguang Yuan, Yajie Gong, Siwei Li, Xuquan Qin, Jianxun Hou, Jialin Liu, Siyu Liu, Hui Li, Yijun Chu, Yingjie Wang, Youxue Zhang, Fang Fang, Wenhui Hao, Yuling Gu, Qinchen Fan, Jing Lin, Da Pang, Xianyu Zhang   +19 more
wiley   +1 more source

Advances in Clinical Application of ctDNA in Tumor Detection, Screening, Prognosis and Treatment

Zhongliu Fangzhi Yanjiu, 2020
Circulating tumor DNA (ctDNA) is a tumor-derived fragmented DNA in blood and is a characteristic marker of tumor. Through the correlative detection of ctDNA, the trace information of the tumor in the blood of the patients can be detected, and the ...
LIU Yong
doaj   +1 more source

Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE):a multicenter observational study [PDF]

, 2018
BACKGROUND: Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluation of the resection specimen ...
, Bartels-Rutten, A., Beets-Tan, R. G. H., Bennink, R. J., Bergman, J. J., Borggreve, A. S., Brosens, L. A. A., Defize, I. L., Dijkstra, H., Henegouwen, M. I. van Berge, Hulshof, M. C., Lam, M. G. E. H., Meijer, G. J., Mook, S., Muijs, C. T., Mul, V. E. M., Nagengast, W. B., Nederveen, A. J., Noordzij, W., Plukker, J. T. M., Ruurda, J. P., ter Beek, L. C., van Dieren, J. M., van Hillegersberg, R., van Laarhoven, H. W. M., van Lier, A. L. H. M. W., van Rossum, P. S. N., van Sandick, J. W., Verheij, M., Voncken, F. E. M., Weusten, B. L. A. M., Yakar, D.   +31 more
core   +4 more sources