Results 131 to 140 of about 28,326 (256)

Oligoprogressive renal cell carcinoma: What is the role of surgery?

BJU International, EarlyView.
Objective To provide an overview of the biological mechanism and pattern of oligoprogression in renal cell carcinoma (RCC) and the most updated role of surgery in this setting, highlighting scientific gaps and informing future implications. Methods A non‐systematic search of PubMed/MEDLINE was performed in August 2025 including guidelines, reviews, and
Chiara Re, William H.J. Ince, Leo Bickley, James P. Blackmur, Mouhamad H. Ismail, Justicia Kyeremeh, Teele Kuusk, Eva Mendes Serrao, James O. Jones, Grant D. Stewart   +9 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

The association of blood ctDNA levels to mutations of marker genes in colorectal cancer

, 2023
Background: Colorectal cancer (CRC) is a deadly and commonly diagnosed cancer. Cell‐free circulating tumor DNAs (ctDNA) have been used in the diagnosis and treatment of CRC, but there are open questions about the relationship between ctDNAs and CRC ...
Zou, Qingliang, Xu, Lin, Han, Xiaorong, Zhang, Chi, Lu, Tao, Zhou, Huijun, Lv, Xinlin, Du, Qian, Bai, Fei, Dong, Wei   +9 more
core  

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

Clinical value of ctDNA in upper-GI cancers: A systematic review and meta-analysis

, 2017
The recent expanding technical possibilities to detect tumor derived mutations in blood, so-called circulating tumor DNA (ctDNA), has rapidly increased the interest in liquid biopsies. This review and meta-analysis explores the clinical value of ctDNA in
Krausz, S., Reinten, R. J., M. Strijker, F. Dijk, Besselink, M. G., van der Wel, M. J., H.W.M. van Laarhoven, C.J.M. van Noesel, Verheij, J., Soer, E. C., M.G. Besselink, van Laarhoven, H. W.M., A. Creemers, M.F. Bijlsma, Dijk, F., van Oijen, M. G.H., Bijlsma, M. F., van Oijen, M. G. H., M.J. van de Vijver, Meijer, S. L., van Noesel, C. J.M., M.J. van der Wel, Wilmink, J. W., S.L. Meijer, J.W. Wilmink, E.C. Soer, van de Vijver, M. J., van Laarhoven, H. W. M., M.G.H. van Oijen, Strijker, M., J. Verheij, S. Krausz, R.J. Reinten, van Noesel, C. J. M., Creemers, A.   +34 more
core   +1 more source

Population‐Based Identification of Clonal Hematopoiesis Using Peripheral Blood Whole‐Genome Sequencing in Japan

Cancer Science, EarlyView.
Whole‐genome sequencing of ~50,000 individuals from the Tohoku Medical Megabank (TMM) cohort defines the prevalence, mutational landscape, and age dependency of clonal hematopoiesis in the Japanese population, demonstrating overall concordance with clonal hematopoiesis detected in cancer patients.
SungGi Chi, Ikuko N. Motoike, Takao Fujisawa, Yumi Yamaguchi‐Kabata, Takahiro Nobukuni, Kengo Kinoshita, Yoshiaki Nakamura, Hideaki Bando, Takayuki Yoshino, Kinuko Ohneda, Katsuya Tsuchihara, Yosuke Minami, Riu Yamashita   +12 more
wiley   +1 more source

Plasma EGFR mutation ctDNA dynamics in patients with advanced EGFR-mutated NSCLC treated with Icotinib: phase 2 multicenter trial result

Scientific Reports
Plasma epidermal growth factor receptor mutation (EGFRm) circulating tumor DNA (ctDNA) dynamics exhibit promise in predicting outcomes in patients with EGFRm-advanced non-small cell lung cancer (NSCLC).
Yaping Hong, Wu Zhuang, Jinhuo Lai, Haipeng Xu, Yueming He, Jinlan Lin, Qin Shi, Shengjia Chen, Zhangzhou Huang, Shijie Chen, Dongzhu Lu, Gen Lin, Yunjian Huang   +12 more
doaj   +1 more source

Molecular profiling of well-differentiated neuroendocrine tumors:Role of ctDNA

, 2021
Introduction: Tumor molecular profiling has proven relevant for the clinicalmanagement of cancer. Circulating tumor DNA (ctDNA) may be a usefulsurrogate of tumor tissue when this is insufficient for analysis.
Valle, Juan, Barriuso, Jorge, Mansoor, Was, Kapacee, Zainul, Frizziero, Melissa, Mcnamara, Mairead; id_orcid, Hubner, Richard, Lamarca, Angela   +7 more
core  

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

ctDNA predicts outcomes in DLBCL [PDF]

Nature Reviews Clinical Oncology, 2018
openaire   +2 more sources