Results 161 to 170 of about 29,283 (270)

Early Local Treatment Delays Multiple Metastases in Non‐Small Cell Lung Cancer With Solitary Distant Metastasis: A Multicenter Retrospective Cohort Study

MedComm, Volume 7, Issue 9, September 2026.
In NSCLC patients with solitary distant metastasis (SDM), early local treatment significantly delays the progression to multi‐metastasis by 14 months (HR = 0.55) compared to delayed or no treatment. This multicenter cohort study highlights SDM as an indolent state, emphasizing the critical time window for effective local intervention. .
Kang Miao, Siyu Lei, Xiaobin Zheng, Shanshan Yang, Yujing Li, Sihui Chen, Qian Miao, Longfeng Zhang, Zihua Zou, Haipeng Xu, Gen Lin   +10 more
wiley   +1 more source

Circulating Tumor DNA in Merkel Cell Carcinoma: A Precision Biomarker for Recurrence Detection and Therapeutic Guidance. [PDF]

J Pers Med
Chan JE, Zaba LC.
europepmc   +1 more source

Dynamic Granulocyte Turnover Inferred From cfDNA Methylation Predicts Immunotherapy Benefit in Liver‐Metastatic Small Cell Lung Cancer: A Prospective Biomarker Study

MedComm, Volume 7, Issue 9, September 2026.
This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang, Xiaoling Shang, Yulan Sun, Yingqian Zhang, Haiyan Zhou, Shucheng Ye, Xiaoyong Tang, Jun Guo, Xiqin Zhang, Xuan Gao, Zhehai Wang, Haiyong Wang   +11 more
wiley   +1 more source

Perioperative ctDNA as a prognostic biomarker in endometrial cancer - the CODEC study. [PDF]

Transl Oncol
Delahunty R, Jayawardana M, Arnolda R, Koh TT, Hofman MS, Reid K, Lamont J, Nguyen-Ngo C, Johnston HM, Brooks NG, Wojtowicz P, Obers VJ, Jobling T, Shadbolt C, Smith PE, Sawyer BL, Xu H, Silva SSM, Neesham D, Ellis J, Goss G, Volchek M, Jones K, Hewitt CA, Fellowes A, Prince HM, McNally O, Wong SQ, Christie EL, Yannakou CK.   +29 more
europepmc   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Liquid biopsy: a step forward in laboratory medicine

Advances in Laboratory Medicine
Díaz-Lagares Angel, Jiménez Wladimiro
doaj   +1 more source

ESR1-Guided Endocrine Switching in HR-Positive Metastatic Breast Cancer: From Detection to Risk-Adapted Decision in SERENA-6 [PDF]

Journal of Immunotherapy and Precision Oncology
Atlal Abusanad
doaj   +1 more source

Circulating tumour DNA in patients with colorectal cancer undergoing curative-intent LIver MEtastases Surgery in France: a prospective, multicentre GERCOR G-118 CLIMES PRODIGE 77 cohort study protocol. [PDF]

BMJ Open
Meskauskas A, Cohen R, Vernerey D, Bachet JB, Lacroix L, Laurent-Puig P, Paye F, Di Fiore F, Boige V, Garcia-Larnicol ML, Evrard C, Goumard C, Gelli M.   +12 more
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Plasma ctDNA as a Treatment Response Biomarker in Metastatic Cancers: Evaluation by the RECIST Working Group

Early indicators of metastatic cancer response to therapy are important for evaluating new drugs and stopping ineffective treatment. The RECIST guidelines based on repeat cancer imaging are widely adopted in clinical trials, are used to identify active ...
Karlovich, CA, Seymour, L, Mateo, J, Schwartz, L, Tolmeijer, SH, Rothwell, D, Cabel, L, Alfano, C, Pantel, K, Petrie, J, The RECIST ctDNA workshop group, Bidard, FC, Attard, G, Rolfo, C, Alberu, XV, Garralda, E, Mizoguchi, C, Wyatt, AW, Bogaerts, J, Needham, J, Shankar, L, Alix-Panabières, C, Shaw, J, Calvo, E, Chen, AP, Dyrskjøt, L, Sudo, K, Tie, J, Toledo, RA, Laurie, SA, Ignatiadis, M, Philip, R, Yap, C, Ford, R, Parsons, H, Dancey, J, Andrews, HS, Williams, M, Stewart, M, De Vries, EGE, Vellanki, PJ, Mizusawa, J, Litiere, S   +42 more
core   +1 more source