Results 171 to 180 of about 36,124 (280)

Visualizing and Quantifying microRNA‐Induced DNA Origami Separation at the Nanoscale

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
Clinically relevant miRNA biomarkers trigger the disassembly of DNA origami dimers into monomers through a toehold‐mediated strand displacement reaction. High‐speed AFM was used to visualize this reaction in real time, while solid‐state nanopore measurements quantified the populations of dimers and monomers, as well as the resulting miRNA concentration,
Chalmers C. C. Chau, Varun Gupta, George R. Heath, Christoph Wälti, Paolo Actis   +4 more
wiley   +2 more sources

Circulating Tumour DNA and Extracellular Vesicle-Associated DNA as Biomarkers for Cancer Detection: A Systematic Review and Meta-Analysis. [PDF]

J Extracell Biol
Wu T, Dickinson K, Schiller I, Tsering T, Chen Y, Nadeau A, Dendukuri N, Agnihotram VR, Burnier JV.   +8 more
europepmc   +1 more source

GCC2 in Small Extracellular Vesicles as a Diagnostic and Prognostic Biomarker of Early‐Stage Lung Adenocarcinoma

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Plasma sEV‐GCC2 enables early detection and prognostic stratification of lung adenocarcinoma. This multicenter study integrates biomarker validation with functional evidence, supporting sEV‐GCC2 as a clinically relevant biomarker. ABSTRACT Emerging evidence suggests that GRIP and coiled‐coil domain‐containing two enriched small extracellular vesicles ...
Byeong Hyeon Choi, Hyonggin An, Sukki Cho, Sungsoo Lee, Hyeong Ryul Kim, Jong Ho Cho, Jun Hee Lee, Ga Yoon Kim, Ok Hwa Jeon, Hyunku Shin, Yeonho Choi, Hyun Koo Kim   +11 more
wiley   +1 more source

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Clinical Validation of Digital PCR-Based ctDNA Detection for Risk Stratification in Residual Triple-Negative Breast Cancer: TRICIA Trial Results. [PDF]

Clin Cancer Res
Roseshter T, Klemantovich A, Lafleur J, Lan C, Cavallone L, Bozek K, Guay J, Elebute O, Jenna S, Ouellette R, McNamara S, Boileau JF, Pelmus M, Brackstone M, Pezo R, Ng T, Aguilar-Mahecha A, Basik M.   +17 more
europepmc   +1 more source

Predictive Value of Circulating Tumor Cells in Neoadjuvant Chemoimmunotherapy for Non‐Small Cell Lung Cancer

Thoracic Cancer, Volume 17, Issue 9, May 2026.
Preoperative CK+ CTC monitoring may serve as a promising adjunct to conventional imaging for predicting pathological response in patients receiving neoadjuvant chemoimmunotherapy. Our exploratory findings suggest that systemic CTC dissemination is associated with a microenvironmental convergence of local hypoxia and attenuated immune signaling ...
Jianyi Yang, Ziwen Qin, Zhiwei Zhou, Jixian Liu, Lin Chen, Ziyan Mo, Mengying Liao, Dongliang Cui, Kaiqin Wu, Dongjiang Tang, Jinfeng Chen, Chao Chen   +11 more
wiley   +1 more source

ctDNA Dynamics and Recurrence Patterns after Organ-Sparing Trimodality Therapy for Bladder Cancer. [PDF]

Clin Cancer Res
Epstein IB, Odogiyon A, Berg S, Otani Y, Mantia C, Pompa IR, Mossanen M, Wan J, Saraf A, Preston M, Ravi A, Carvalho F, Herberts C, ElNaggar A, Clinton T, Roberts D, Peng L, McGregor B, Bellmunt J, Kamran SC, Berchuck JE, Efstathiou JA, Miyamoto DT, Mouw KW.   +23 more
europepmc   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source

Feasibility of <i>TP53</i>-Mutated ctDNA Monitoring in High-Grade Endometrial Cancer Using Routine NGS. [PDF]

Cancers (Basel)
Marlin R, Jean-Laurent M, Joachim C, Vallard A, Pennont S, Suez-Panama V, Rose M, Ulric-Gervaise S, Lusbec S, Bera O, Aline-Fardin A, Ebring C.   +11 more
europepmc   +1 more source

Rituximab/bendamustine and rituximab/cytarabine induction therapy for transplant-eligible mantle cell lymphoma [PDF]

, 2020
al., et, Bartlett, Nancy L., Cashen, Amanda, Edwin, Natasha, Ghobadi, Armin, Kahl, Brad, Mehta-Shah, Neha, Merryman, Reid W.   +7 more
core   +1 more source