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Review ctDNA and Breast Cancer
2019In only few years, circulating tumor DNA (ctDNA) in breast cancer has moved from purely fundamental research to nearby daily use for treatment selection and drug-resistance assessment. Indeed, technical advances and widespread use of next-generation sequencing or digital PCR allowed for detection of very low amount of tumor DNA in bloodstream.
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Abstract LB106: Ultra-short ctDNA: A new paradigm for ctDNA liquid biopsy
Cancer ResearchAbstract Mononucleosomal ctDNA (mnctDNA, 157-bp, double-stranded) spearheads liquid biopsy (LB) for cancer detection, treatment and clinical care. The bottleneck of mnctDNA LB are low copy number of ctDNA and limit of detection of platform technologies.
Feng Li +8 more
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ctDNA-guided adjuvant immunotherapy in colorectal cancer
ImmunotherapyCirculating tumor DNA (ctDNA) represents a powerful measure of minimal residual disease (MRD) in colorectal cancer (CRC). Although immunotherapy has been widely established in metastatic CRC that is mismatch repair deficient or microsatellite instability-high (dMMR/MSI-H), its role in non-metastatic CRC is rapidly evolving.
Nicholas, Burley +11 more
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Hochrisiko-Melanom: Rezidivprädiktion durch postoperative ctDNA
Im Focus Onkologie, 2018Nach Resektion eines Hochrisiko-Melanoms mit BRAF- oder NRAS-Mutation nachgewiesene zirkulierende Tumor-DNA ist ein praziser Rezidivpradiktor und damit fur die Patientenauswahl fur eine adjuvante Therapie geeignet.
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Post-surgical ctDNA in patients with CRC
Nature Reviews Gastroenterology & Hepatology, 2023openaire +2 more sources