Results 81 to 90 of about 47,434 (363)

Evaluation of pre-analytical factors affecting plasma DNA analysis. [PDF]

, 2018
Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample quality and the impact of pre-analytical processing. To address this gap and to evaluate effects of
Berens, Michael E, Borad, Mitesh J, Bryce, Alan, Contente-Cuomo, Tania, Dhruv, Harshil D, Farooq, Maria, Gollins, Simon, Liang, Winnie S, LoRusso, Patricia M, Markus, Havell, Murtaza, Muhammed, Ribas, Antoni, Sekulic, Aleksandar, Sivakumar, Shivan, Tran, Nhan L, Trent, Jeffrey M   +15 more
core   +1 more source

Baseline ctDNA gene alterations as a biomarker of survival after panitumumab and chemotherapy in metastatic colorectal cancer

Nature Network Boston
Certain genetic alterations and right-sided primary tumor location are associated with resistance to anti-epidermal growth factor (EGFR) treatment in metastatic colorectal cancer (mCRC).
K. Shitara, K. Muro, J. Watanabe, K. Yamazaki, H. Ohori, Manabu Shiozawa, A. Takashima, Mitsuru Yokota, A. Makiyama, N. Akazawa, Hitoshi Ojima, Yasuhiro Yuasa, Keisuke Miwa, H. Yasui, E. Oki, Takeo Sato, Takeshi Naitoh, Yoshito Komatsu, T. Kato, I. Mori, Kazunori Yamanaka, M. Hihara, Junpei Soeda, Toshihiro Misumi, Kouji Yamamoto, Riu Yamashita, K. Akagi, A. Ochiai, H. Uetake, K. Tsuchihara, T. Yoshino   +30 more
semanticscholar   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Prognostic Value of Postoperative Circulating Tumor DNA in Patients With Early- and Intermediate-Stage Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Majority of patients with resected early- and intermediate-stage liver cancer will experience postoperative recurrence. This study aimed to investigate the application of ctDNA sequencing in the postoperative period of hepatocellular carcinoma.
Ke Ye, Qinqiao Fan, Mingming Yuan, Dong Wang, Liang Xiao, Guo Long, Rongrong Chen, Tongdi Fang, Zengbo Li, Ledu Zhou   +9 more
doaj   +1 more source

Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. [PDF]

, 2018
BackgroundNew prognostic markers are needed to identify patients with Ewing sarcoma (EWS) and osteosarcoma unlikely to benefit from standard therapy.
Barkauskas, Donald A, Clapp, Andrea, Crompton, Brian D, DuBois, Steven G, Gorlick, Richard, Ha, Gavin, Hall, David, Imamovic-Tuco, Alma, Janeway, Katherine A, Klega, Kelly, Krailo, Mark D, Leavey, Patrick J, Lessnick, Stephen L, London, Wendy B, Mascarenhas, Leo, Nag, Anwesha, Shulman, David S, Stegmaier, Kimberly, Thorner, Aaron R, Van Allen, Eliezer, Vo, Kieuhoa T   +20 more
core   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy

Frontiers in Oncology
Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and extracellular vehicles (EVs) have received significant attention in recent times as emerging biomarkers and subjects of transformational studies.
Xiaoling Wang, Lijuan Wang, Haihong Lin, Yifan Zhu, Defa Huang, Mi Lai, Xuxiang Xi, Junyun Huang, Wenjuan Zhang, Tianyu Zhong   +9 more
semanticscholar   +1 more source

Utility of ctDNA in predicting response to neoadjuvant chemoradiotherapy and prognosis assessment in locally advanced rectal cancer: A prospective cohort study

PLoS Medicine, 2021
Background For locally advanced rectal cancer (LARC) patients who receive neoadjuvant chemoradiotherapy (nCRT), there are no reliable indicators to accurately predict pathological complete response (pCR) before surgery.
Yaqi Wang, Li-feng Yang, H. Bao, Xiaojun Fan, F. Xia, J. Wan, L. Shen, Y. Guan, Hairong Bao, Xue Wu, Yang Xu, Y. Shao, Yiqun Sun, T. Tong, Xinxiang Li, Ye Xu, S. Cai, Ji Zhu, Zhen Zhang   +18 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative [PDF]

, 2016
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies.
Aberra, Metasebia, Bender, R. Joseph, Brody, Jonathan, Chung, Vincent, Heartwell, Craig, Hendifar, Andrew, Hoos, William A., Madhavan, Subha, Mason, Kimberly, Matrisian, Lynn M., Mikhail, Sam, Petricoin, Emanuel, III, Picozzi, Vincent, Pishvaian, Michael J., Rahib, Lola, Varieur, Katelyn   +15 more
core   +2 more sources