Results 81 to 90 of about 39,021 (326)

Monitoring ctDNA RAS Mutational Status in Metastatic Colorectal Cancer: A Trial Protocol of RAS-trace and RAS-trace-2 Studies

Journal of the Anus, Rectum and Colon
Background: Spatial and temporal heterogeneities of RAS and other molecular genes should be considered in the treatment of metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs ...
Kozo Kataoka, Takeshi Yamada, Manabu Shiozawa, Naoto Takase, Kazuma Ito, Kentaro Yamazaki, Jun Watanabe, Toshihiro Kudo, Takeshi Suto, Toshihiko Matsumoto, Kohei Murata, Yusuke Suwa, Shogen Boku, Hisateru Yasui, Nobuhisa Matsuhashi, Atsuyuki Maeda, Kiichi Sugimoto, Yusuke Matsumoto, Mitsuru Yokota, Johannes Fredebohm, Keita Mori, Masataka Ikeda   +21 more
doaj   +1 more source

AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection. [PDF]

, 2016
BACKGROUND: The single hotspot mutation AKT1 [G49A:E17K] has been described in several cancers, with the highest incidence observed in breast cancer. However, its precise role in disease etiology remains unknown. METHODS: We analyzed more than 600 breast
Anzeneder, Tobias, Beckmann, Georg, Byrne, Annette T, Jeffers, Michael, Köchert, Karl, Pena, Carol, Politz, Oliver, Reischl, Joachim, Rudolph, Marion, Schulz, Anke, Vonk, Richardus   +10 more
core   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
ABSTRACT The blood‐brain barrier (BBB) renders the delivery of nanomedicine in the brain ineffective and the detection of circulating disease‐related DNA from the brain unreliable. Here, we demonstrate that microbubble‐enhanced focused ultrasound (MB‐FUS) mediated BBB opening, supported by large‐data models predict sonication regimens for safe and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

Circulating Tumor DNA in Primary and Secondary Liver Cancers: A Comprehensive Review

Frontiers in Bioscience-Scholar
Similar to many other cancer types, liver malignancies pose the common challenges of late detection of primary tumors and recurrences. Liquid biopsies, which assess the presence of circulating tumor DNA, have emerged as a novel, non-invasive clinical ...
Hanna Hong, Chase J Wehrle, Omer Faruk Karakaya, Noah Tocci, Pranav Kumar, Keyue Sun, Chunbao Jiao, Sangeeta Satish, Rebecca Panconesi, Jamak Modaresi Esfeh, Maureen Whitsett Linganna, Koji Hashimoto, Andrea Schlegel, Charles Miller, David C.H. Kwon, Federico Aucejo   +15 more
doaj   +1 more source

Genomic Assessment of Blood-Derived Circulating Tumor DNA in Patients With Colorectal Cancers: Correlation With Tissue Sequencing, Therapeutic Response, and Survival. [PDF]

, 2019
PurposeGenomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with colorectal cancers were correlated with clinical outcomes.Patients and methodsNext-generation sequencing of ctDNA (54- to 73-gene panel) was performed in 94 ...
Fanta, Paul T, Kato, Shumei, Kurzrock, Razelle, Lanman, Richard B, Leichman, Lawrence, Lippman, Scott M, Okamura, Ryosuke, Raymond, Victoria M, Schwaederlé, Maria C, Talasaz, AmirAli   +9 more
core   +1 more source

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors. [PDF]

, 2018
BACKGROUND: Diffuse anaplastic Wilms tumor (DAWT) is a rare, high-risk subtype that is often missed on diagnostic needle biopsy. Somatic mutations in TP53 are associated with the development of anaplasia and with poorer survival, particularly in advanced-
Al-Saadi, Reem, Brok, Jesper, Butcher, Robert, Chagtai, Tasnim, Cresswell, George D, Luscombe, Nicholas M, Mifsud, William, Pritchard Jones, Kathy, Roberts, Chrissy, Treger, Taryn D, Williams, Richard D   +10 more
core   +2 more sources

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Intra-Tumor Heterogeneity of Colorectal Cancer Necessitates the Multi-Regional Sequencing for Comprehensive Mutational Profiling

Cancer Management and Research, 2021
Shaohua Guo,1,2,* Yumeng Ye,3,* Xinyi Liu,4 Yuan Gong,5 Mingyan Xu,4 Lele Song,4,6 Hongyi Liu1 1Department of General Surgery, The First Medical Center of the Chinese PLA General Hospital, Beijing, People’s Republic of China; 2Department of ...
Guo S, Ye Y, Liu X, Gong Y, Xu M, Song L, Liu H   +6 more
doaj  

Perioperative ctDNA-Based MRD Detection in NSCLC— Letter [PDF]

, 2022
Shixiong Wei, Xinliang Gao, Mingbo Tang, Jialin Li, Kewei Zhang, Linan Fang, Jingyao Dong, Wei Liu   +7 more
openalex   +1 more source

ctDNA as a Cancer Biomarker: A Broad Overview

Critical Reviews in Oncology/Hematology, 2020
Circulating tumor DNA (ctDNA) in fluids has gained attention because ctDNA seems to identify tumor-specific abnormalities, which could be used for diagnosis, follow-up of treatment, and prognosis: the so-called liquid biopsy. Liquid biopsy is a minimally invasive approach and presents the sum of ctDNA from primary and secondary tumor sites. It has been
Pessoa, Luciana Santos, Heringer, Manoela, Ferrer, Valéria Pereira   +2 more
openaire   +3 more sources