Results 71 to 80 of about 2,662 (167)

Comparative Genomics Provide Insights Into Karyotype Evolution in Vespertilionid Bats (Vespertilionidae, Chiroptera)

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Studies elucidating the molecular basis and evolutionary consequences of karyotypic changes in mammals remain scarce. Here, we investigate chromosomal evolution by focusing on two contrasting lineages within the family Vespertilionidae (Chiroptera): the karyotypically variable tribe Pipistrellini and the highly conserved genus Myotis ...
Linjing Lan, Xin Zhang, Jinjin Xie, Xiaohui Lin, Xihong Hong, Wenhui Nie, Jinhuan Wang, Weiting Su, Fengtang Yang, Guimei He, Xiuguang Mao   +10 more
wiley   +1 more source

The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens

Frontiers in Veterinary Science, 2020
Collagen triple helix repeat containing-1 (CTHRC1) has recently been identified as avian leukosis virus subgroup J (ALV-J) replication-dependent factor that remarkably facilitates ALV-J replication via interaction with the envelope glycoprotein (SU) of ...
Yu Pang, Defang Zhou, Jing Zhou, Jingwen Xue, Yiya Wang, Ziqiang Cheng   +5 more
doaj   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Expression and role of CTHRC1 in inflammatory bowel disease in children

Cytotechnology
Inflammatory bowel disease (IBD) is a chronic, progressive, immune-mediated, gastrointestinal inflammatory disease with increasing occurrences in children. Collagen triple helix repeat containing 1 (CTHRC1), a migration-promoting protein, acts as a tumor-promoting factor in malignant tumors.
Tang, Heng, Gao, Xiang, Wu, Zhaofang, Chen, Jia, Chen, Li, Du, Xiang   +5 more
openaire   +2 more sources

Collagen triple helix repeat-containing 1 protein: an emerging biomarker and its influence on the clinical and sonographic disease severity in Egyptian medicated female rheumatoid arthritis patients

Egyptian Rheumatology and Rehabilitation
Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of synovial joints, with a multifactorial etiology. Collagen triple helix repeat-containing 1 protein (CTHRC1) is a biomarker produced by fibroblast-like synoviocytes ...
Shaden Essam, Diaa Fahmy Mohasseb, Noha A. Elsawy, Neveen Lewis Mikhael Saad, Yousra Hisham Abdel-Fattah   +4 more
doaj   +1 more source

CTHRC1+ cancer associated-fibroblasts promotes malignant progression of bladder cancer cells via inducing an immunosuppressive tumor microenvironment

Frontiers in Immunology
IntroductionBladder cancer remains a therapeutic challenge due to its high recurrence and metastasis rates. Cancer-associated fibroblasts (CAFs) are recognized as pivotal regulators of the tumor microenvironment (TME), however the specific contribution ...
Miao Wang, Meng Lin, Yang Wang
doaj   +1 more source

Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1

Respiratory Research, 2019
Background Pirfenidone, an antifibrotic agent used for the treatment of idiopathic pulmonary fibrosis (IPF), functions by inhibiting myofibroblast differentiation, which is involved in transforming growth factor (TGF)-β1-induced IPF pathogenesis. However,
Jin Jin, Shinsaku Togo, Kotaro Kadoya, Miniwan Tulafu, Yukiko Namba, Moe Iwai, Junko Watanabe, Kumi Nagahama, Takahiro Okabe, Moulid Hidayat, Yuzo Kodama, Hideya Kitamura, Takashi Ogura, Norikazu Kitamura, Kazuho Ikeo, Shinichi Sasaki, Shigeru Tominaga, Kazuhisa Takahashi   +17 more
doaj   +1 more source

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

Cancer Cell International, 2019
Background This study aimed to investigate the prognostic value of the potential biomarker collagen triple helix repeat containing 1 (CTHRC1) in lung adenocarcinoma (LUAD) patients.
Yangshan Chen, Yu Sun, Yongmei Cui, Yiyan Lei, Neng Jiang, Wenting Jiang, Han Wang, Lili Chen, Jiping Luo, Yanyang Chen, Kejing Tang, Chengzhi Zhou, Zunfu Ke   +12 more
doaj   +1 more source

The role of CTHRC1 in promotion of cutaneous wound healing

Signal Transduction and Targeted Therapy, 2022
Xianlan Duan, Xingyu Yuan, Bin Yao, Wei Song, Zhao Li, null Enhejirigala, Yi Kong, Yuzhen Wang, Xiaobing Fu, Sha Huang   +9 more
openaire   +3 more sources

Serum Collagen Triple Helix Repeat Containing-1 Levels are Related to Radiological Affection and Disease Activity in Rheumatoid Arthritis

Open Access Rheumatology: Research and Reviews, 2022
Eman Mostafa Nassef,1 Hemmat Ahmed Elabd,2 Hala Mohamed Elzomor,2 Basma Mohamed Mohamed Ali El Nagger,2 Amira Shahin Ibrahim,2 Amal Hussein Ibrahim,1 Hend Gamal Kotb,1 Donia Ahmed Hassan,3 Rasha Elsayed Mohamed Abd ElAziz,4 Eman El Sayed Mohamed3 ...
Nassef EM, Elabd HA, Elzomor HM, El Nagger BMMA, Ibrahim AS, Ibrahim AH, Kotb HG, Hassan DA, Abd ElAziz REM, Mohamed EES   +9 more
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