Results 61 to 70 of about 2,662 (167)

RELB Overexpression Induced by DNA Hypomethylation Contributes to Perioperative Immunotherapy Resistance in Resectable Esophageal Squamous Cell Carcinoma by Modulating the mregDC‐Treg Axis

Cancer Medicine, Volume 15, Issue 5, May 2026.
In patients with resectable ESCC, DNA hypomethylation driven RELB overexpression promotes resistance to perioperative immunotherapy (neoadjuvant ICIs followed by surgery and adjuvant ICIs). High RELB expression correlates with increased infiltration of mature immunoregulatory dendritic cells (mregDCs) and regulatory T cells (Tregs) in the tumor ...
Lijuan Gao, Shaobo Ke
wiley   +1 more source

DEC1 Deficiency Attenuates Breast Cancer‐Induced Osteolytic Destruction by Suppression of Cancer‐Associated Fibroblast Differentiation

Cancer Medicine, Volume 15, Issue 5, May 2026.
Schematic diagram of the mechanism by which DEC1 deficiency attenuates breast cancer‐induced osteolytic destruction through suppression of cancer‐associated fibroblast differentiation. ABSTRACT Background Cancer‐associated fibroblasts (CAFs) in the bone microenvironment play a key role in breast cancer (BC) osteolytic bone metastases.
Zhiyi Qiang, Ying Huo, Lan Lin, Kaiao Chen, Wei Liu, Jian Yang   +5 more
wiley   +1 more source

Identification of CTHRC1 as a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma by Bioinformatics Analysis

Translational Oncology
Background: Esophageal squamous cell carcinoma (ESCC) carries one of the highest case-fatality rates among gastrointestinal malignancies, owing in part to the scarcity of molecularly validated prognostic indicators.
Shuoguoli Li, Yongan Kang, Yijun Qi
doaj   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, Volume 10, Issue 10, 22 May 2026.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

A step ahead on CTHRC1, and not just reinventing the wheel!

Chinese Clinical Oncology, 2019
The association of CTHRC1 with tumor progression is demonstrated in various human cancers, including hepatocellular carcinoma, gastric cancer, pancreatic cancer, GIST and colorectal cancer (1-3). In a meta-analysis done by Wang et al ., the results revealed correlation of CTHRC1 expression with TNM stage in gastric cancer, breast cancer, and ...
Siddharth, Turkar, Anant, Ramaswamy, Vikas, Ostwal   +2 more
openaire   +3 more sources

Matrifibrocytes Redefine Cardiac Fibrosis: From Terminal Differentiation to Translational Modulation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Cardiac fibrosis is increasingly recognized as a dynamic program that resolves into a terminal fibroblast fate, the matrifibrocyte, rather than a persistent myofibroblast state. Lineage‐tracing and single‐cell studies reveal that matrifibrocytes arise from activated myofibroblasts during late scar maturation, lose α‐SMA and proliferative ...
Zhentao Zhang, Hua Zhu
wiley   +1 more source

CTHRC1 (Collagen Triple Helix Repeat Containing 1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CTHRC1 (Collagen Triple Helix Repeat Containing 1), with data on DNA, on the protein encoded, and where the gene is implicated.
LeClair, R, Durmus, T, Lindner, V
openaire   +2 more sources

Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signalingResearch in context

EBioMedicine, 2019
Background: Hepatic fibrosis is caused by chronic liver injury and may progress toward liver cirrhosis, and even hepatocellular carcinoma. However, current treatment is not satisfactory.
Jun Li, Yahui Wang, Mingze Ma, Shuheng Jiang, Xueli Zhang, Yanli Zhang, Xiaomei Yang, Chunjie Xu, Guangang Tian, Qing Li, Yang Wang, Lei Zhu, Huizhen Nie, Mingxuan Feng, Qiang Xia, Jianren Gu, Qing Xu, Zhigang Zhang   +17 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, Volume 20, Issue 4, Page 947-961, April 2026.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Patient‐Derived 3D Bioprinted Cardiac Organoid Constructs Reveal Key Pathological Features of Duchenne Muscular Dystrophy

Advanced Healthcare Materials, Volume 15, Issue 16, 24 April 2026.
Patient‐derived cardiac organoids reveal key features of Duchenne muscular dystrophy cardiomyopathy, including apoptosis, oxidative stress, calcium handling defects, and mechanical remodeling. By integrating organoids into alginate–gelatin bioprinted constructs, disease phenotypes are organized into scalable 3D cardiac tissues displaying extracellular ...
Vittoria Marini, Margalida Campaner Socias, Andreas Dimopoulos, Lorenza Rinvenuto, Enrico Pozzo, Diana Stalkopf, Angelo Serafini, Sara Morri, Ashley Wang, Rita La Rovere, Yoke Chin Chai, Sveva Bollini, Geert Bultynck, H. Llewelyn Roderick, Ioannis Papantoniou, Maurilio Sampaolesi   +15 more
wiley   +1 more source