Results 41 to 50 of about 2,662 (167)

Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1 [PDF]

Bone, 2017
Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we characterized the bone phenotype of a novel Cthrc1 null mouse strain using bone histomorphometry, μCT analysis and functional readouts for bone ...
Yong-Ri Jin, J. Patrizia Stohn, Qiaozeng Wang, Kenichi Nagano, Roland Baron, Mary L. Bouxsein, Clifford J. Rosen, Vyacheslav A. Adarichev, Volkhard Lindner   +8 more
openaire   +2 more sources

CTHRC1 modulates cell proliferation and invasion in hepatocellular carcinoma by DNA methylation

Discover Oncology
Background Collagen triple helix repeat containing-1 (CTHRC1), an extracellular matrix protein, is highly expressed in hepatocellular carcinoma (HCC) and linked to poor prognosis. Nevertheless, the precise mechanism of CTHRC1 in HCC is unclear.
Xiangjun Sun, Ye Liu, Changdong Cheng, Haoyu Sun, Liqiang Tian   +4 more
doaj   +1 more source

Collagen triple helix repeat containing 1 (CTHRC1) activates Integrin β3/FAK signaling and promotes metastasis in ovarian cancer

Journal of Ovarian Research, 2017
Background Metastasis is the major cause of morbidity and mortality in patients with epithelial ovarian cancer (EOC), however the mechanisms that underline this process are poorly understood. Collagen triple helix repeat containing-1 (CTHRC1) is a 28-kDa
Biying Guo, Huan Yan, Luying Li, Kemin Yin, Fang Ji, Shu Zhang   +5 more
doaj   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis

Frontiers in Genetics, 2022
Background: Gastric cancer (GC) is a common cancer with high mortality. This study aimed to identify its differentially expressed genes (DEGs) using bioinformatics methods.Methods: DEGs were screened from four GEO (Gene Expression Omnibus) gene ...
Chenyu Sun, Yue Chen, Na Hyun Kim, Scott Lowe, Shaodi Ma, Zhen Zhou, Rachel Bentley, Yi-Sheng Chen, Margarita Whitaker Tuason, Wenchao Gu, Chandur Bhan, John Pocholo Whitaker Tuason, Pratikshya Thapa, Ce Cheng, Ce Cheng, Qin Zhou, Yanzhe Zhu   +16 more
doaj   +1 more source

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

Cancer Science, EarlyView.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia, Fengming Xu, Tao Zhou, Pingping Wang, Huiping Chen, Jing Zhang, Xiaochen Yuan, Haoxun Xu, Yu Ouyang   +8 more
wiley   +1 more source

Estimation levels of CTHRC1and some cytokines in Iraqi patients with Rheumatoid Arthritis

مجلة بغداد للعلوم, 2023
Collagen triple helix repeat containing-1 (CTHRC1) is an essential marker for Rheumatoid Arthritis (RA), but its relationship with pro-inflammatory, anti-inflammatory, and inflammatory markers has been scantily covered in extant literature.
Ahmed R. Oleiwi, Ayaid Khadem Zgair
doaj   +1 more source

Human Embryonic Stem Cell‐Derived Immunity‐And‐Matrix‐Regulatory Cells Attenuate Pulmonary Fibrosis via MMP1‐Mediated Collagen Degradation

Cell Proliferation, EarlyView.
Human embryonic stem cell‐derived Immunity‐and‐Matrix‐Regulatory Cells (IMRCs) effectively attenuate pulmonary fibrosis by secreting Matrix Metalloproteinase‐1 (MMP1), which directly degrades excess collagen I in the extracellular matrix. By directly degrading collagen I, IMRCs reverse ECM stiffness, suppress myofibroblast activation, and promote a ...
Zhongwen Li, Dingyun Song, Faguo Sun, Licheng Song, Bin An, Tingting Gao, Jingjing Liu, Kan Zhang, Kaidi Liu, Kaiwei Wu, Yajing Li, Yi Yang, Yaru Liu, Ruofan Su, Zai Wang, Tiemei Zhao, Huaiyong Chen, Li Xiao, Liang Peng, Liu Wang, Wei Li, Lixin Xie, Jie Hao, Huaping Dai, Jun Wu   +24 more
wiley   +1 more source

CTHRC1 May Serve As A Prognostic Biomarker For Hepatocellular Carcinoma.

OncoTargets and therapy, 2019
Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression.
Zhou,Huifang, Su,Libo, Liu,Chao, Li,Baosheng, Li,Hui, Xie,Ying, Sun,Dianxing   +6 more
openaire   +3 more sources

CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway

Advanced Science
Tendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is
Cheng Chen, Xu Zheng, Cheng Wang, HaiChao Zhou, Yi Zhang, TianBao Ye, YunFeng Yang   +6 more
doaj   +1 more source