Results 21 to 30 of about 2,662 (167)

CTHRC1 targeted by miR-30a-5p regulates cell adhesion, invasion and migration in lung adenocarcinoma

Journal of Cardiothoracic Surgery, 2022
The morbidity of lung cancer ranks first among all cancers. Lung adenocarcinoma (LUAD) is a classification of lung cancer, and cell invasion and migration of LUAD are the main causes for its high mortality.
Chaomian Yang, Tianxia Huang, Yue Liang, Yanlong Xue, Ying Liang, Xianqin Wei, Fangchan Meng, Qiu Wei   +7 more
doaj   +1 more source

Cthrc1 is a negative regulator of myelination in schwann cells [PDF]

Glia, 2011
AbstractThe analysis of the molecular mechanisms involved in the initial interaction between neurons and Schwann cells is a key issue in understanding the myelination process. We recently identified Cthrc1 (Collagen triple helix repeat containing 1) as a gene upregulated in Schwann cells upon interaction with the axon. Cthrc1 encodes a secreted protein
Caroline, Apra, Laurence, Richard, Fanny, Coulpier, Corinne, Blugeon, Pascale, Gilardi-Hebenstreit, Jean-michel, Vallat, Volkhard, Lindner, Patrick, Charnay, Laurence, Decker   +8 more
openaire   +2 more sources

Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis. [PDF]

PLoS ONE, 2013
Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found that the CTHRC1 gene is overexpressed in hepatocellular carcinoma (HCC ...
Yu-Ling Chen, Ting-Huang Wang, Hey-Chi Hsu, Ray-Hwang Yuan, Yung-Ming Jeng   +4 more
doaj   +1 more source

Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors. [PDF]

PLoS ONE, 2014
An increasing number of studies report that Cthrc1 is expressed in various cancer cells. The present study sought to identify which cells in tumors and remodeling tissues express Cthrc1 and investigate the range of circulating human Cthrc1 levels in ...
Christine W Duarte, J Patrizia Stohn, Qiaozeng Wang, Ivette F Emery, Andrew Prueser, Volkhard Lindner   +5 more
doaj   +1 more source

Pan-cancer analysis combined with experiments predicts CTHRC1 as a therapeutic target for human cancers

Cancer Cell International, 2021
Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1
Dazhao Peng, Cheng Wei, Xiaoyang Zhang, Shenghui Li, Hao Liang, Xingyu Zheng, Shulong Jiang, Lei Han   +7 more
doaj   +1 more source

CTHRC1 facilitates bladder cancer cell proliferation and invasion through regulating the PI3K/Akt signaling pathway

Archives of Medical Science, 2019
Introduction Emerging evidence has illustrated that Collagen triple helix repeat containing 1 (CTHRC1) is crucial for tumorigenesis and development. However, the effects of CTHRC1 on bladder cancer progression remain largely unclear.
Yubing Li, Xiangdong Cheng, Jiasheng Yan, Shaobo Jiang   +3 more
doaj   +1 more source

The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets

Frontiers in Genetics, 2022
Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. However, its specific role and mechanism with immune infiltrates in gastric cancer are still unclear ...
Lulu Zhao, Wanqing Wang, Penghui Niu, Xiaoyi Luan, Dongbing Zhao, Yingtai Chen   +5 more
doaj   +1 more source

CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9

BMC Cancer, 2018
Background The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion.
Weiling He, Hui Zhang, Yuefeng Wang, Yanbin Zhou, Yifeng Luo, Yongmei Cui, Neng Jiang, Wenting Jiang, Han Wang, Di Xu, Shuhua Li, Zhuo Wang, Yangshan Chen, Yu Sun, Yang Zhang, Hsian-Rong Tseng, Xuenong Zou, Liantang Wang, Zunfu Ke   +18 more
doaj   +1 more source

CTHRC1: An Emerging Biomarker in Lung Fibrosis

, 2023
Pulmonary fibrosis is a chronic, progressive, and irreversible lung disease characterized by fibrotic scarring in the lung parenchyma. This condition involves the excessive accumulation of extracellular matrix (EM) due to a persistently activated wound-repair response.
Zhussipbek Mukhatayev, Altynay Adilbayeva, Jeannette Kunz   +2 more
openaire   +1 more source

Fibroblast-associated CTHRC1 as a key indicator of recurrence risk in prostate cancer. [PDF]

World J Surg Oncol
Ma Y, Lin G, Wang K, Liu Z, Shao Y, Yu W, Zhao X, Yu D, Zhan F, Wang X, Duan S, Duan K.   +11 more
europepmc   +3 more sources