Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders [PDF]
Frontiers in Aging NeuroscienceBackgroundCognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. We identified CTHRC1 (Collagen Triple Helix Repeat Containing 1) as a novel candidate associated with cognitive
Jie Xu +8 more
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CTHRC1: A New Candidate Biomarker for Improved Rheumatoid Arthritis Diagnosis [PDF]
Frontiers in Immunology, 2019 Background: The purpose of this study was to determine whether plasma levels of the collagen triple helix repeat containing 1 (CTHRC1) protein can serve as a blood-based biomarker for improved diagnosis of rheumatoid arthritis (RA) patients and ...
Jeannette Kunz +2 more
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Cthrc1 is a positive regulator of osteoblastic bone formation. [PDF]
PLoS ONE, 2008 Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteoclasts and bone formation by osteoblasts. This remodeling process is regulated by many systemic and local factors.We identified collagen triple helix ...
Hiroaki Kimura +8 more
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Cthrc1, a novel circulating hormone regulating metabolism. [PDF]
PLoS ONE, 2012 We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not
J Patrizia Stohn +4 more
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Identification of CTHRC1 as a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma by Bioinformatics Analysis [PDF]
Translational OncologyBackground: Esophageal squamous cell carcinoma (ESCC) carries one of the highest case-fatality rates among gastrointestinal malignancies, owing in part to the scarcity of molecularly validated prognostic indicators.
Shuoguoli Li, Yongan Kang, Yijun Qi
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CTHRC1+ cancer associated-fibroblasts promotes malignant progression of bladder cancer cells via inducing an immunosuppressive tumor microenvironment [PDF]
Frontiers in ImmunologyIntroductionBladder cancer remains a therapeutic challenge due to its high recurrence and metastasis rates. Cancer-associated fibroblasts (CAFs) are recognized as pivotal regulators of the tumor microenvironment (TME), however the specific contribution ...
Miao Wang, Meng Lin, Yang Wang
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Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma [PDF]
Frontiers in Molecular Biosciences, 2022 Colon adenocarcinoma (COAD), ranking third in incidence and second in mortality, is one of the most common cancer types in the world. The initial stages of COAD usually show no obvious clinical symptoms; moreover, effective screening or diagnostic ...
Chen Pang +3 more
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The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis [PDF]
Mediators of Inflammation, 2020 Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue ...
Dan Mei +3 more
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The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets
Frontiers in Genetics, 2022 Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. However, its specific role and mechanism with immune infiltrates in gastric cancer are still unclear ...
Wanqing Wang
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The Mechanism Of Cthrc1 In The Osteogentic Differentation Of Hpdlscs
International Dental JournalAim or purpose: To investigate the role and underlying mechanisms of collagen triple helix repeat containing 1 (CTHRC1) in the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs). Materials and methods: 1.
Zhihui Ye, Zhou Rui
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