Results 1 to 10 of about 2,662 (167)

CTHRC1: a key player in colorectal cancer progression and immune evasion [PDF]

Frontiers in Immunology
The multifunctional secreted protein, collagen triple helix repeat containing 1 (CTHRC1), has recently emerged as a significant focus within oncology research.
Qingjie Chen, Haohao Wang, Qinghua Liu, Changjiang Luo   +3 more
exaly   +6 more sources

Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders [PDF]

Frontiers in Aging Neuroscience
BackgroundCognitive dysfunction affects over 50 million individuals worldwide, with Alzheimer’s disease (AD) representing two-thirds of cases. We identified CTHRC1 (Collagen Triple Helix Repeat Containing 1) as a novel candidate associated with cognitive
Jie Xu, Jie Xu, Yuan He, Zhao Li, Wenrong Zhou, Chunjian Huang, Lu Lu, Akhilesh K. Bajpai, Min Li   +8 more
doaj   +4 more sources

CTHRC1: An Emerging Hallmark of Pathogenic Fibroblasts in Lung Fibrosis

Cells
Pulmonary fibrosis is a chronic, progressive, irreversible lung disease characterized by fibrotic scarring in the lung parenchyma. This condition involves the excessive accumulation of extracellular matrix (ECM) due to the aberrant activation of ...
Jeannette Kunz, Altynai Adilbayeva
exaly   +5 more sources

CTHRC1/TGF-β/Smad axis serves as therapeutic targets in inhibiting oral squamous cell carcinoma by mediating ferroptosis [PDF]

Discover Oncology
Background Collagen triple helix repeat containing 1 (CTHRC1) is an oncogene in numerous human cancers including oral squamous cell carcinoma (OSCC). However, whether and how CTHRC1 influences OSCC progression through ferroptosis has not been completely ...
Shihao Huang, Yiming Jiao, Yongchun Chang, Yu Feng, Guixian Mu, Linli Xie   +5 more
doaj   +2 more sources

CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway [PDF]

Cancer Medicine
Background Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein involved in tissue remodeling and fibrotic processes, which also suggests emerging roles in cancer.
Hang Yin, Yue Pan, Zhuang Li, Yong Liu, Jiatong Chen, Xin Chen, Chengfei Zhang, Feng Zhu, Chunzhao Yu   +8 more
doaj   +2 more sources

CTHRC1 overexpression predicts poor survival and enhances epithelial‐mesenchymal transition in colorectal cancer

Cancer Medicine, 2018
Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related factor, is a promigratory protein involved in multiple processes, including vascular remodeling, antifibrosis, metabolism, bone formation, and cancer.
Zhaohui Huang, Weiwei Weng, Dan Huang
exaly   +2 more sources

CTHRC1-driven breast cancer progression: insights from palmitoylation networks and spatial heterogeneity [PDF]

BMC Cancer
This study systematically screened palmitoylation-related key biomarkers in breast cancer and constructed a high-precision diagnostic model combining multi-omics data and machine learning algorithms.
Shujia Yu, Jingyu Wu
doaj   +2 more sources

Expression, Prognostic Value, and Biological Function of CTHRC1 in Different Types of Gliomas: A Bioinformatic Analysis and Experiment Validation

Clinical Medicine Insights: Oncology
Background: In recent years, abnormal expression of collagen triple helix repeat containing 1 (CTHRC1) has been found in some tumors, closely related to the poor prognosis of cancer patients. However, the clinical significance of CTHRC1 in gliomas is not
Guangtang Chen, Xiaolin Du
exaly   +2 more sources

Mechanistic study of CTHRC1 in promoting Wilms’ tumor progression by regulating M2-type tumor-associated macrophages polarization [PDF]

Journal of Translational Medicine
Background This study aimed to investigate the role of Collagen triple helix repeat protein 1 (CTHRC1) in Wilms’ tumor (WT) progression and elucidate its molecular mechanism in promoting WT malignancy through regulation of M2-type tumor-associated ...
Yingquan Zhuo, Xiaoyun Feng, Wenqi Zhang, Jun Du, Xu Sun, Xi Luo, Wei Wang, Hua Jiang, Huajian Gu   +8 more
doaj   +2 more sources

Exosomal CTHRC1 from cancer-associated fibroblasts facilitates endometrial cancer progression via ITGB3/FAK signaling pathway

Heliyon
The emerging tumor microenvironment (TME) is a complex and constantly evolving entity. Cancer-associated fibroblasts (CAFs) are a vital component of the TME with diverse functions.
Yiding Bian, Bilan Li, Yunfeng Song
exaly   +3 more sources