Vascular Pharmacology, 2023 CTHRC1 is transiently expressed by activated fibroblasts during tissue repair and in certain cancers, and CTHRC1 derived from osteocytes is detectable in circulation. Because its biological activity is poorly understood, we investigated whether the N terminus of CTHRC1 encodes a propeptide requiring cleavage to become activated.
Sergey Ryzhov +2 more
exaly +5 more sources
CTHRC1: An Emerging Hallmark of Pathogenic Fibroblasts in Lung Fibrosis
CellsPulmonary fibrosis is a chronic, progressive, irreversible lung disease characterized by fibrotic scarring in the lung parenchyma. This condition involves the excessive accumulation of extracellular matrix (ECM) due to the aberrant activation of ...
Zhussipbek Mukhatayev +2 more
doaj +4 more sources
CTHRC1: a key player in colorectal cancer progression and immune evasion [PDF]
Frontiers in ImmunologyThe multifunctional secreted protein, collagen triple helix repeat containing 1 (CTHRC1), has recently emerged as a significant focus within oncology research.
Qingjie Chen +3 more
doaj +4 more sources
Overexpression of CTHRC1 in hepatocellular carcinoma promotes tumor invasion and predicts poor prognosis. [PDF]
PLoS ONE, 2013 Collagen triple helix repeat containing-1 (CTHRC1) is a secreted glycoprotein that activates the planar cell polarity pathway of Wnt signaling. Using microarray analysis, we found that the CTHRC1 gene is overexpressed in hepatocellular carcinoma (HCC ...
Yu-Ling Chen +4 more
doaj +3 more sources
CTHRC1 induces non-small cell lung cancer (NSCLC) invasion through upregulating MMP-7/MMP-9
BMC Cancer, 2018 Background The strong invasive and metastatic nature of non-small cell lung cancer (NSCLC) leads to poor prognosis. Collagen triple helix repeat containing 1 (CTHRC1) is involved in cell migration, motility and invasion.
Weiling He +18 more
doaj +2 more sources
CTHRC1 Attenuates Tendinopathy via Enhancing EGFR/MAPK Signaling Pathway
Advanced ScienceTendinopathy poses a formidable challenge due to the inherent limitations of tendon regenerative capabilities post‐injury. At present, effective curative approaches for tendinopathy are still lacking. Collagen triple helix repeat‐containing 1 (CTHRC1) is
Cheng Chen +6 more
doaj +2 more sources
CTHRC1 drives megakaryocyte-mediated immunotherapy resistance in esophageal squamous cell carcinoma via the integrin αIIbβ3/Rap1 pathway and is targetable by mRNA vaccination [PDF]
Molecular CancerThe clinical efficacy of immunotherapy in advanced esophageal squamous cell carcinoma (ESCC) remains suboptimal, as most patients eventually develop drug resistance and experience disease progression.
Yixin Liu +14 more
doaj +2 more sources
Cancer Medicine, 2018 Collagen triple helix repeat containing (CTHRC1), which was identified as a cancer‐related factor, is a promigratory protein involved in multiple processes, including vascular remodeling, antifibrosis, metabolism, bone formation, and cancer.
Cong Tan, Zhaohui Huang, Weiwei Weng
exaly +2 more sources
CTHRC1/TGF-β/Smad axis serves as therapeutic targets in inhibiting oral squamous cell carcinoma by mediating ferroptosis [PDF]
Discover OncologyBackground Collagen triple helix repeat containing 1 (CTHRC1) is an oncogene in numerous human cancers including oral squamous cell carcinoma (OSCC). However, whether and how CTHRC1 influences OSCC progression through ferroptosis has not been completely ...
Shihao Huang +5 more
doaj +2 more sources
Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1 [PDF]
Bone, 2017 Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic differentiation and positive regulation of bone mass, however, the underlying mechanisms remain unclear. Here we characterized the bone phenotype of a novel Cthrc1 null mouse strain using bone histomorphometry, μCT analysis and functional readouts for bone ...
Yong-Ri Jin +8 more
core +5 more sources