CTHRC1 targeted by miR-30a-5p regulates cell adhesion, invasion and migration in lung adenocarcinoma
Journal of Cardiothoracic Surgery, 2022 The morbidity of lung cancer ranks first among all cancers. Lung adenocarcinoma (LUAD) is a classification of lung cancer, and cell invasion and migration of LUAD are the main causes for its high mortality.
Chaomian Yang +7 more
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Fibroblast-associated CTHRC1 as a key indicator of recurrence risk in prostate cancer. [PDF]
World J Surg OncolMa Y +11 more
europepmc +3 more sources
Elevated plasma levels of the pituitary hormone Cthrc1 in individuals with red hair but not in patients with solid tumors. [PDF]
PLoS ONE, 2014 An increasing number of studies report that Cthrc1 is expressed in various cancer cells. The present study sought to identify which cells in tumors and remodeling tissues express Cthrc1 and investigate the range of circulating human Cthrc1 levels in ...
Christine W Duarte +5 more
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Cancer Cell International, 2021 Background The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1
Dazhao Peng +7 more
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Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. [PDF]
, 2010 An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression.
Heil, S.G. +9 more
core +1 more source
Archives of Medical Science, 2019 Introduction Emerging evidence has illustrated that Collagen triple helix repeat containing 1 (CTHRC1) is crucial for tumorigenesis and development. However, the effects of CTHRC1 on bladder cancer progression remain largely unclear.
Yubing Li +3 more
doaj +1 more source
Macrophage-to-Myofibroblast Transdifferentiation Contributes to Pulmonary Fibrosis via the MERTK-SPP1-SRC-TKS5 Signaling Axis. [PDF]
Adv Sci (Weinh)MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Wei Y, Guo H, Yang X, Tang XX.
europepmc +2 more sources
CTHRC1: An Emerging Biomarker in Lung Fibrosis
, 2023 Pulmonary fibrosis is a chronic, progressive, and irreversible lung disease characterized by fibrotic scarring in the lung parenchyma. This condition involves the excessive accumulation of extracellular matrix (EM) due to a persistently activated wound-repair response.
Zhussipbek Mukhatayev +2 more
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Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation [PDF]
Journal of Clinical Investigation, 2013 Bone remodeling is characterized by the sequential, local tethering of osteoclasts and osteoblasts and is key to the maintenance of bone integrity. While bone matrix-mobilized growth factors, such as TGF-β, are proposed to regulate remodeling, no in vivo evidence exists that an osteoclast-produced molecule serves as a coupling factor for bone ...
Sunao, Takeshita +7 more
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Intracellular Localization of Cthrc1 Characterizes Differentiated Smooth Muscle [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 Objective— We recently reported expression of collagen triple helix repeat containing-1 (Cthrc1) in injured arteries and proteolytic cleavage of Cthrc1 in smooth muscle cells in vitro. The present study characterizes Cthrc1 processing and determines its biological significance.
Renée J, Leclair +4 more
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