Results 191 to 200 of about 69,132 (251)

Genomic, Trop‐2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear.
Tomomi Sakamaki, Tatsuyuki Chiyoda, Kohei Nakamura, Reika Takamatsu, Ryutaro Kawano, Daisuke Ochiai, Mitsuyo Jisaka, Mio Takahashi, Takuma Yoshimura, Yumiko Kimura, Shinya Oki, Kensuke Sakai, Tomoko Yoshihama, Hiroshi Nishihara, Wataru Yamagami   +14 more
wiley   +1 more source

Correlation of the peripheral blood DNA methylation profile and immune‐related adverse events in patients with solid cancer treated with immune checkpoint inhibitors

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Baseline blood DNA methylation profiles predict early immune‐related adverse events across cancer types. A methylation‐based classifier demonstrated robust discriminatory performance and revealed enrichment of neuronal and developmental regulatory pathways, suggesting a systemic epigenetic predisposition to immune toxicity following immune checkpoint ...
Markus Kleinberger, Angelika Martina Starzer, Erwin Tomasich, Julia Maria Berger, Vincent Sunder‐Plassmann, Lynn Gottmann, Isabella Solano Henao, Martin Korpan, Josef Fuerst, Nikola Vladic, Cihan Ay, Helmuth Haslacher, Julia Furtner, Matthias Preusser, Gerwin Heller, Anna Sophie Berghoff   +15 more
wiley   +1 more source

IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2⁺ regulatory T cells. [PDF]

Nat Commun
Ganchiku Y, Ribas GT, Lima K, Gassen RB, Liu K, Efe O, Griffith JW, Luster AD, Shriver Z, Babcock GJ, Rosales IA, LeGuern C, Borges TJ, Riella LV.   +13 more
europepmc   +1 more source

Peripheral immune dynamics during treatment predict prognosis in HCC receiving TACE plus ICIs and anti‐VEGF/TKIs

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
Abstract Objectives To evaluate the prognostic value of peripheral immune markers and their static and dynamic changes during different treatment stages in patients with hepatitis B virus (HBV)‐related unresectable hepatocellula carcinoma (uHCC) receiving transarterial chemoembolisation (TACE) combined with immune checkpoint inhibitors (ICIs) and anti ...
Lihao Qin, Linzhou Zhu, Hao Yang, Wanci Li, Shuai Zhang, Jian Shen, Xiaoli Zhu   +6 more
wiley   +1 more source

Comprehensive Review of Immunotherapy in Colorectal Cancer: From Mechanisms to Nursing Interventions. [PDF]

Immunotargets Ther
Zhu Q, Lai Y, Zhao J, Zhang Z, Cui X, Kou M.   +5 more
europepmc   +1 more source

SLC7A5 promotes colorectal cancer liver metastasis by reprogramming tryptophan metabolism through the Kyn/XANA‒AhR axis and reshaping the immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
SLC7A5‒Kyn/XANA signalling activates AhR to drive EMT and metastatsis. SLC7A5 knockdown enhances macrophage antigen presentation and reverses CD8+ T‐cell exhaustion. SLC7A5 knockdown induces antigen‐driven and IgG‐secreting B‐cell clonal expansion. Combination of SLC7A5 inhibition and anti‐PD‐1 therapy offers clinical targeting.
Yaohao Luo, Lei Li, Shanbao Li, Xinshuai Wang, Zeping He, Fangbin Song, Jun Qin, Jinyan Zhang, Junming Xu   +8 more
wiley   +1 more source

Immune-Mediated Hypophysitis: An Updated Review. [PDF]

J Clin Med
Iglesias P.
europepmc   +1 more source

Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +4 more
wiley   +1 more source

Regulatory T cells in breast cancer drivers of immune suppression and targets for immunotherapy. [PDF]

Front Immunol
Pan T, Shao N, Ming R, Zhou G, Pei Y, Deng J.   +5 more
europepmc   +1 more source