Results 201 to 210 of about 69,132 (251)
The Impact of Oral‐Gut Microbiota Structure and Its Manipulation on RA Development and Management
(A) Schematic representation of oral–gut microbiota composition in health and rheumatoid arthritis (RA), highlighting the enrichment of beneficial microorganisms (green) under healthy conditions and the expansion of pathogenic microorganisms (orange) in RA‐associated dysbiosis.
Parisa Ahmadi +8 more
wiley +1 more source
Immune regulatory mechanisms in the tumor microenvironment and their applications in cancer therapy: from basic research to clinical translation. [PDF]
Feng Y, Wang Y, Li X, Wang Y, Zhang M.
europepmc +1 more source
ABSTRACT Background and Aims Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high‐risk patients.
Mosammat Jannatul Mawa +3 more
wiley +1 more source
BCG Induces PD-1 Upregulation on Circulating CD8<sup>+</sup> T Cells and IL-6 and IL-8 Secretion <i>In Vitro</i>. [PDF]
Barbosa GR +7 more
europepmc +1 more source
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta +2 more
wiley +1 more source
First-in-human study of intravenous bispecific CTLA-4 × OX40 antibody (ATOR-1015) in advanced solid malignancies. [PDF]
Ekström-Rydén V +7 more
europepmc +1 more source
The Dual Role of the Gut Microbiota in Cancer Chemoresistance
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi +3 more
wiley +1 more source
Advances in Immune Checkpoint Inhibitors for Cancer Treatment. [PDF]
Chen K, Zhu F, Li X, Yoshimura T.
europepmc +1 more source
Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar +12 more
wiley +1 more source

