Results 221 to 230 of about 69,132 (251)
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CTLA-4 blockade of antigen-induced cell death
Blood, 2001AbstractWhile cytotoxic T lymphocyte antigen–4 (CTLA-4) negatively regulates T-cell receptor (TCR)–driven interleukin (IL)–2 production and proliferation, little is known regarding whether the coreceptor has the capacity to inhibit other events, such as Fas ligand (FasL) expression and antigen-induced cell death (AICD).
S, da Rocha Dias, C E, Rudd
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Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen
Blood, 2000The idiotypic determinant (Id) of the immunoglobulin expressed by a B-cell malignancy can serve as an effective tumor-specific antigen but is only weakly immunogenic. This study demonstrates that the immunogenicity of the tumor Id protein can be dramatically increased by directing it to antigen-presenting cells (APCs). Cytotoxic T-lymphocyte antigen 4 (
T H, Huang +6 more
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Influence of cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms in periodontitis
Archives of Oral Biology, 2012Persistent host inflammatory immune response against the pathogens results in the destruction of periodontal tissues. Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production.
B, Houshmand, A, Rafiei, M, Hajilooi
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Markers for Anti-cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Therapy in Melanoma
2013Therapeutic strategies that block Cytotoxic T lymphocyte antigen-4 (CTLA-4) enhance antitumor immunity and prolong the lives of patients with metastatic melanoma. However, only a subset of patients benefit, and responses are often delayed due to heterogeneous response kinetics.
Michael A, Postow +4 more
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CTLA-4-dependent trogocytosis promotes the interactions between Tregs and antigen-presenting cells
The Journal of Immunology, 2020Abstract Regulatory T cells (Tregs) are responsible for the maintenance of immune homeostasis. They express the coinhibitory receptor CTLA-4 in high quantities, whose loss causes severe systemic autoinflammation in both mice and humans.
Murat Tekguc +4 more
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Identification of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) isoforms in the Pekin duck
Developmental & Comparative Immunology, 2010Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4, CD152) is an inhibitory T cell receptor predominately expressed on activated T cells. The duck CTLA-4 (DuCTLA-4) cDNA and a transcript lacking the predicted transmembrane encoding region (DuCTLA-4DeltaTM) were isolated from splenocytes using RT-PCR.
Qingxia, Yao +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 2021
Murat Tekgüç +2 more
exaly
Murat Tekgüç +2 more
exaly
Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus.
Clinical and experimental rheumatology, 2000Genetic susceptibility to systemic lupus erythematosus (SLE) is conferred not only by various genes within the major histocompatibility complex (MHC) region, but also by several other non-MHC linked genes. The negatively signalling molecule CTLA-4 is involved in establishing and maintaining of peripheral T cell tolerance, which controls T cell ...
R, Pullmann +8 more
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