Results 261 to 270 of about 94,347 (282)

CTLA-4 blockade of antigen-induced cell death

Blood, 2001
AbstractWhile cytotoxic T lymphocyte antigen–4 (CTLA-4) negatively regulates T-cell receptor (TCR)–driven interleukin (IL)–2 production and proliferation, little is known regarding whether the coreceptor has the capacity to inhibit other events, such as Fas ligand (FasL) expression and antigen-induced cell death (AICD).
S, da Rocha Dias, C E, Rudd
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B70 antigen is a second ligand for CTLA-4 and CD28

Nature, 1993
The membrane antigen B7/BB1 (refs 1, 2) is expressed on activated B cells, macrophages and dendritic cells, and binds to a counter-receptor, CD28, expressed on T lymphocytes and thymocytes. Interaction between CD28 and B7 results in potent costimulation of T-cell activation initiated through the CD3/T-cell receptor complex.
M, Azuma, D, Ito, H, Yagita, K, Okumura, J H, Phillips, L L, Lanier, C, Somoza   +6 more
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Influence of cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphisms in periodontitis

Archives of Oral Biology, 2012
Persistent host inflammatory immune response against the pathogens results in the destruction of periodontal tissues. Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a particularly important molecule in down-regulating T-cell expansion and cytokine production.
B, Houshmand, A, Rafiei, M, Hajilooi
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Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen

Blood, 2000
The idiotypic determinant (Id) of the immunoglobulin expressed by a B-cell malignancy can serve as an effective tumor-specific antigen but is only weakly immunogenic. This study demonstrates that the immunogenicity of the tumor Id protein can be dramatically increased by directing it to antigen-presenting cells (APCs). Cytotoxic T-lymphocyte antigen 4 (
T H, Huang, P Y, Wu, C N, Lee, H I, Huang, S L, Hsieh, J, Kung, M H, Tao   +6 more
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CTLA-4-dependent trogocytosis promotes the interactions between Tregs and antigen-presenting cells

The Journal of Immunology, 2020
Abstract Regulatory T cells (Tregs) are responsible for the maintenance of immune homeostasis. They express the coinhibitory receptor CTLA-4 in high quantities, whose loss causes severe systemic autoinflammation in both mice and humans.
Murat Tekguc, James Badger Wing, Motonao Osaki, Jia Long, Shimon Sakaguchi   +4 more
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Markers for Anti-cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Therapy in Melanoma

2013
Therapeutic strategies that block Cytotoxic T lymphocyte antigen-4 (CTLA-4) enhance antitumor immunity and prolong the lives of patients with metastatic melanoma. However, only a subset of patients benefit, and responses are often delayed due to heterogeneous response kinetics.
Michael A, Postow, Jianda, Yuan, Shigehisa, Kitano, Alexander M, Lesokhin, Jedd D, Wolchok   +4 more
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Cystine‐knot peptides targeting cancer‐relevant human cytotoxic T lymphocyte‐associated antigen 4 (CTLA‐4)

Journal of Peptide Science, 2015
Cystine‐knot peptides sharing a common fold but displaying a notably large diversity within the primary structure of flanking loops have shown great potential as scaffolds for the development of therapeutic and diagnostic agents. In this study, we demonstrated that the cystine‐knot peptide MCoTI‐II, a trypsin inhibitor from Momordica cochinchinensis ...
Franziska, Maaß, Joycelyn, Wüstehube-Lausch, Stephan, Dickgießer, Bernhard, Valldorf, Michael, Reinwarth, Hans-Ulrich, Schmoldt, Matin, Daneschdar, Olga, Avrutina, Ugur, Sahin, Harald, Kolmar   +9 more
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Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy

The Lancet, 1999
Smoking and demographic variables are known to be risk factors for the development of thyroid-associated orbitopathy (TAO) among patients with Graves' hyperthyroidism, but a firm genetic basis for TAO has not been established. We show that the presence and severity of TAO are associated with an allele of the cytotoxic T lymphocyte antigen-4-gene.
B, Vaidya, H, Imrie, P, Perros, J, Dickinson, M I, McCarthy, P, Kendall-Taylor, S H, Pearce   +6 more
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A DNA vaccine against cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) prevents tumor growth

Biochemical and Biophysical Research Communications, 2013
Co-stimulatory signaling pathway triggered by the binding of B7.1/B7.2 (CD80/86) of antigen-presenting cells (APCs) to CD28 of T cells is required for optimal T-cell activation. Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T cell activation, which competes with CD28 for B7.1/B7.2 binding with a greater affinity ...
Keng-Hsueh, Lan, Yu-Chang, Liu, Yi-Sheng, Shih, Chang-Liang, Tsaid, Sang-Hue, Yen, Keng-Li, Lan   +5 more
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