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Identification of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) isoforms in the Pekin duck
Developmental & Comparative Immunology, 2010Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4, CD152) is an inhibitory T cell receptor predominately expressed on activated T cells. The duck CTLA-4 (DuCTLA-4) cDNA and a transcript lacking the predicted transmembrane encoding region (DuCTLA-4DeltaTM) were isolated from splenocytes using RT-PCR.
Qingxia, Yao +6 more
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American Journal of Hematology, 2004
AbstractThe CTLA‐4 molecule plays an important role in immune regulation by downregulating activation of T cells. Polymorphisms in the CTLA‐4 gene have been shown to be associated to a number of autoimmune diseases including blood disorders. In this study, the intragenic polymorphisms of the CTLA‐4 gene at position −318*C/T, +49*A/G, and the ...
Maria, Monne +7 more
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AbstractThe CTLA‐4 molecule plays an important role in immune regulation by downregulating activation of T cells. Polymorphisms in the CTLA‐4 gene have been shown to be associated to a number of autoimmune diseases including blood disorders. In this study, the intragenic polymorphisms of the CTLA‐4 gene at position −318*C/T, +49*A/G, and the ...
Maria, Monne +7 more
openaire +2 more sources
SAT0564 Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) Expressed in Human Mesenchymal Stromal Cells
Annals of the Rheumatic Diseases, 2014Background The Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) is an inhibitory costimulatory molecule of the CD28 family, predominantly found on both regulatory T cells and activated T cells. It plays a crucial role in conveying immune tolerance by adjusting the threshold of T cell activation in inflammatory disorders and in regenerative processes such as ...
K. Schönbeck +8 more
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Thrombosis Research, 2015
Previously, we demonstrated the importance of T-cell immune response cDNA 7 (TIRC7) in acute immune thrombocytopenia (ITP). As the downstream molecule of TIRC7, cytotoxic T lymphocyte antigen-4 (CTLA-4) has been verified its negative regulation of acute ITP.
Feng, Zhu +11 more
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Previously, we demonstrated the importance of T-cell immune response cDNA 7 (TIRC7) in acute immune thrombocytopenia (ITP). As the downstream molecule of TIRC7, cytotoxic T lymphocyte antigen-4 (CTLA-4) has been verified its negative regulation of acute ITP.
Feng, Zhu +11 more
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Tissue Antigens, 2003
Abstract Eastern woodchuck (Marmota monax) became an important animal model to study the immunological processes in hepatitis B virus infection. To facilitate further study of T‐cell responses in this model, we cloned and sequenced the cDNAs of Woodchuck CD28 and cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4), which play important roles for the ...
D, Yang, M, Roggendorf, M, Lu
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Abstract Eastern woodchuck (Marmota monax) became an important animal model to study the immunological processes in hepatitis B virus infection. To facilitate further study of T‐cell responses in this model, we cloned and sequenced the cDNAs of Woodchuck CD28 and cytotoxic T‐lymphocyte‐associated antigen 4 (CTLA‐4), which play important roles for the ...
D, Yang, M, Roggendorf, M, Lu
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Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus.
Clinical and experimental rheumatology, 2000Genetic susceptibility to systemic lupus erythematosus (SLE) is conferred not only by various genes within the major histocompatibility complex (MHC) region, but also by several other non-MHC linked genes. The negatively signalling molecule CTLA-4 is involved in establishing and maintaining of peripheral T cell tolerance, which controls T cell ...
R, Pullmann +8 more
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Cytotoxic T lymphocyte antigen-4 (CTLA-4) polymorphism in patients with Behçet's disease.
Clinical and experimental rheumatology, 2011Nursen, Düzgün +4 more
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