Frontiers in Pharmacology, 2017 CTX-M-15 type β-lactamase has the ability to hydrolyse cefotaxime, a third generation cephalosporin. The infections caused by multidrug resistant strains, especially CTX-M-15 producing strains are being treated with carbapenem group of β-lactam ...
Lubna Maryam, Asad U. Khan
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Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital [PDF]
, 2016 Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (
Ardanuy Tisaire, María Carmen +11 more
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Detection of CTX-M-15 extended-spectrum -lactamase in the United Kingdom [PDF]
Journal of Antimicrobial Chemotherapy, 2003 528 2 mg/L with MIC50 = 0.5 mg/L and MIC90 = 2.0 mg/L. MBCs for 10 of 12 (83%) isolates were 2–4 times the MIC, indicating bactericidal effect. Plots of time–kill assays for two isolates with levofloxacin MICs = 0.5 mg/L and MBCs = 2 mg/L (4× MIC) are shown in Figure 1.
Mushtaq, Shazad +3 more
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Scientific Reports, 2022 Recently, the emergence and rapid dissemination of extended-spectrum beta-lactamase (ESBL)-producing bacteria, particularly of the family Enterobacteriaceae, has posed serious healthcare challenges.
Samiratu Mahazu +8 more
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Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae. [PDF]
, 2018 Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of studies to evaluate in vivo the efficacy of combinations therapies.
Cebrero Cangueiro, Tania +5 more
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Structural Comparisons of Cefotaximase (CTX-M-ase) Sub Family 1
Frontiers in Microbiology, 2021 The cefotaximase or CTX-M, family of serine-β-lactamases represents a significant clinical concern due to the ability for these enzymes to confer resistance to a broad array of β-lactam antibiotics an inhibitors.
Ben A. Shurina +2 more
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Characterisation of OXA-244, a chromosomally-encoded OXA-48-like β-lactamase from Escherichia coli [PDF]
, 2016 International audienceABSTRACT Shewanella spp. constitute a reservoir of antibiotic resistance determinants. In a bile sample, we identified three extended-spectrum-β-lactamase (ESBL)-producing bacteria ( Escherichia coli , Klebsiella pneumoniae , and ...
Dortet, Laurent +3 more
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In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae [PDF]
, 2018 Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of multidrug-resistant Enterobacteriaceae is a public health problem and the World Health Organization pointed them among the pathogens in which
Cebrero Cangueiro, Tania +4 more
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Polymicrobial necrotizing fasciitis involving enterobacteria producing CTX-M-15 extended-spectrum β-lactamases [PDF]
Journal of Medical Microbiology, 2011 Necrotizing fasciitis due to multiple Gram-negative organisms in a Nigerian patient is described. Morganella morganii and Citrobacter freundii carrying the CTX-M-15 extended-spectrum β-lactamase gene were isolated, highlighting the emergence of this β-lactamase in Western Africa and its successful spread amongst a wider range of members of the ...
S, Soleimanian +2 more
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Extended-spectrum β-lactamases, transferable quinolone resistance, and virulotyping in extra-intestinal E. coli in Uruguay [PDF]
, 2016 Introduction: To characterize extended-spectrum β-lactamases (ESBLs) and plasmid-mediated quinolone resistance (PMQR) genes in Escherichia coli isolates obtained from extra-intestinal samples in three Uruguayan hospitals.
Aguerrebere, Paula +10 more
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