Unnatural Amino Acid Incorporation into Virus-Like Particles [PDF]
, 2008 Virus-like particles composed of hepatitis B virus (HBV) or bacteriophage Qβ capsid proteins have been labeled with azide- or alkyne-containing unnatural amino acids by expression in a methionine auxotrophic strain of E. coli.
Brown, Steven +11 more
core +2 more sources
Synthesis of [(1,2,3-Triazol-1-yl)methyl]boronic Acids Through Click Chemistry: Easy Access to a Potential Scaffold for Protease Inhibitors [PDF]
, 2015 Stereoselective synthesis of previously unreported [(1,2,3-triazol-1-yl)methyl]boronic acids has been achieved from azidomethylboronates by copper-catalyzed azide–alkyne cycloaddition reaction.
CASELLI, Emilia +2 more
core +1 more source
Dual modification of biomolecules [PDF]
, 2016 With the advent of novel bioorthogonal reactions and “click” chemistry, an increasing number of strategies for the single labelling of proteins and oligonucleotides have emerged.
Chudasama, V, Maruani, A, Richards, DA
core +1 more source
Revisiting the mechanism of the mono nuclear copper-catalyzed cycloaddition of azide and alkynes (CuAAC) by the topology of .... [PDF]
, 2013 Comunicación presentada y aceptada en el CHITEL2013, XXXIX International Conference THEORETICAL CHEMISTS OF LATIN EXPRESSION (XXXIX Congreso Internacional de Químicos de Expresión Latina).Se analiza el mecanismo de la reacción de cicloadición, catalizada
Calvo-Losada, Saturnino +2 more
core
Chemoselective sequential click ligations directed by enhanced reactivity of an aromatic ynamine [PDF]
, 2016 Aromatic ynamines or N-alkynylheteroarenes are highly reactive alkyne components in Cu-catalyzed Huisgen [3 +2] cycloaddition (“click”) reactions. This enhanced reactivity enables the chemoselective formation of 1,4-triazoles using the representative ...
Burley, Glenn A. +8 more
core +1 more source
Design and Evaluation of Heterobivalent PAR1–PAR2 Ligands as Antagonists of Calcium Mobilization [PDF]
, 2019 A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2.
Arnold, Leggy A. +5 more
core +1 more source
Synthesis of EDTA core dendrimers through a consecutive esterification-CuAAC process [PDF]
, 2017 Artículo para obtención de grado de DoctorA novel class of thermostable G0 and G1-dendrimers was synthesized from the coupling of both propargyl and azido esters derived from EDTA through copper catalyzed azide-alkyne cycloaddition.
Apolonio, Víctor M. +5 more
core +1 more source
RGD-conjugated rod-like viral nanoparticles on 2D scaffold improve bone differentiation of mesenchymal stem cells [PDF]
, 2014 Viral nanoparticles have uniform and well-defined nano-structures and can be produced in large quantities. Several plant viral nanoparticles have been tested in biomedical applications due to the lack of mammalian cell infectivity.
Huong Giang Nguyen +4 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2019 The preparation of new organocatalysts for asymmetric syntheses has become a key stage of enantioselective catalysis. In particular, the development of new cyclodextrin (CD)-based organocatalysts allowed to perform enantioselective reactions in water and
Iveta Chena Tichá +2 more
doaj +1 more source
The Click Reaction as an Efficient Tool for the Construction of Macrocyclic Structures
Molecules, 2013 The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC, known as the click reaction) is an established tool used for the construction of complex molecular architectures.
Dario Pasini
doaj +1 more source