Results 81 to 90 of about 20,694 (254)

PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis

Journal of Orthopaedic Translation, 2021
Objectives Vascularization is an essential step in successful bone tissue engineering. The induction of angiogenesis in bone tissue engineering can be enhanced through the delivery of therapeutic agents that stimulate vessel and bone formation.
Wenxiang Cheng, Yan-zhi Liu, Xiangbo Meng, Zhengtan Zheng, Lingli Li, Liqing Ke, Lingli Li, Cuishan Huang, Guoyuan Zhu, Huiqing Pan, L. Qin, Xin-Luan Wang, Peng Zhang   +12 more
semanticscholar   +1 more source

High‐throughput transcriptome mining and in silico screening reveal saccharide feeding stimulants for Cydia pomonella larvae

New Plant Protection, Volume 3, Issue 1, March 2026.
We identified and characterized the gustatory and ionotropic receptors of Cydia pomonella using transcriptomics and in silico approaches, linking candidate sugar receptors to larval feeding attraction. Functional assays and behavioral tests highlighted isoquercitrin as a key feeding stimulant, providing a foundation for olfactory‐ and taste‐based pest ...
Chenyun Ding, Zaiyuan Li, Qiang Wu, Bo Liu, Fanghao Wan, Cong Huang, Rui Tang   +6 more
wiley   +1 more source

The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A.
Naser Jafargholizadeh, Seyed Jalal Zargar, Younes Aftabi   +2 more
doaj   +1 more source

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade [PDF]

, 2016
OBJECTIVE: Acquired chemoresistance is a major obstacle in the clinical management of ovarian cancer. Therefore, searching for alternative therapeutic modalities is urgently needed.
Al Rawahi T, D. Grahame Hardie, David W. Chan, Ferla R, Fiona A. Ross, Hextan Y. S. Ngan, Jinbiao Zhan, Kikkawa F, Limtrakul P, Mingo M. H. Yung, Pinto AL, Teh MT, Thomas H. Y. Leung   +12 more
core   +3 more sources

Mechanistic Insights for Microbiome Application in Plant Disease Resistance

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
This review summarises the mechanisms underlying plant‐guided microbiome modulation and probiotic‐mediated disease suppression. Additionally, it highlights the challenges to be addressed for a better microbiome application of disease resistance in sustainable agriculture and proposes possible strategies. Figure was created with BioRender.
Jiakang Yin
wiley   +1 more source

Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Lagenaria siceraria (Molina) Standl.]

Plants, 2023
Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize, Hussein Shimelis, Jacob Mashilo   +2 more
doaj   +1 more source

The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas [PDF]

, 2008
Purpose: The signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in most cancers, propagates tumorigenesis, and is a key regulator of immune suppression in cancer patients.
Abou-Ghazal, Mohamed, Fuller, Gregory N., Heimberger, Amy B., Hiroka, Nobuyoshi, Kong, Ling-Yuan, Priebe, Waldemar, Qiao, Wei, Reina-Ortiz, Chantal, Sawaya, Raymond, Wei, Jun, Yang, David S.   +10 more
core   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Cucurbitacin B inhibits proliferation, induces G2/M cycle arrest and autophagy without affecting apoptosis but enhances MTT reduction in PC12 cells

Bangladesh Journal of Pharmacology, 2015
In the present study, the effect of cucurbitacin B (a natural product with anti-cancer effect) was studied on PC12 cells. It significantly reduced the cell number, changed cell morphology and inhibited colony formation while MTT results showed increased ...
Chuanhong Wu, Jiaolin Bao, Chengwei He, Jinjian Lu, Xiuping Chen   +4 more
doaj  

n-Hexane Fraction of Cucumis melo L. Cultivar Gama Melon Parfum: An in vitro Study in MCF7 and T47D Cells Line

MCBS (Molecular and Cellular Biomedical Sciences)
Background: Cucumis melo a melon species, typically has a sweet taste. Some cultivars are known for their distinctive bitter flesh due to its higher levels of cucurbitacin. Cucurbitacin is semipolar compound that has anticancer properties.
Rohmi Salamah, Nastiti Wijayanti, Slamet Widiyanto   +2 more
doaj   +1 more source