Results 61 to 70 of about 15,621 (174)

Population Genetic Differences Between Two Cucurbit Leaf Beetles With Contrasting Feeding Preferences [PDF]

Ecol Evol
The study revealed that the polyphagous A. indica exhibits higher genetic diversity, lower differentiation, and higher gene flow than the oligophagous A. lewisii, with these differences attributed to their distinct dietary preferences. A. lewisii populations showed significant isolation‐by‐distance, whereas A.
He B, Xiao M, Ye T, Lin G, Zhao F, Liu L, Li H, Su T, Huang Z.   +8 more
europepmc   +2 more sources

Mechanistic Insights for Microbiome Application in Plant Disease Resistance

Molecular Plant Pathology, Volume 27, Issue 3, March 2026.
This review summarises the mechanisms underlying plant‐guided microbiome modulation and probiotic‐mediated disease suppression. Additionally, it highlights the challenges to be addressed for a better microbiome application of disease resistance in sustainable agriculture and proposes possible strategies. Figure was created with BioRender.
Jiakang Yin
wiley   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

Multi‐Omics Evidence Linking Gualou Xiebai Banxia Decoction Intervention to Atherosclerosis Mitigation and Gut Microbiota–Bile Acid Signatures in ApoE−/− Mice

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Gualou Xiebai Banxia Decoction (GXBD) promotes atherosclerotic plaque stabilization via the “gut microbiota—bile acid—host” axis. GXBD treatment remodels the gut microbiota, promoting the production of secondary bile acids (11‐LCA and 23‐DCA).
Rutao Bian, Li Zhang, Jun Zhu, Xuegong Xu   +3 more
wiley   +1 more source

Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents

Molecules, 2018
Cucurbitacin B shows potent activity against tumor cells, but its high toxicity limits its application in the clinic. A series of cucurbitacin B derivatives was synthesized and evaluated for their anti-hepatocellular carcinoma (HCC) activities against ...
Weizhi Ge, Xinyi Chen, Fangzhi Han, Zhongquan Liu, Tianpeng Wang, Mengmeng Wang, Yue Chen, Yahui Ding, Quan Zhang   +8 more
doaj   +1 more source

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

Impact of the secondary plant metabolite Cucurbitacin B on the demographical traits of the melon aphid, Aphis gossypii

Scientific Reports, 2018
Cucurbitacin B is a natural triterpene present in plants of Cucurbitaceae family, which are among the host plants for melon aphid, Aphis gossypii. In present study we characterized the effects of two cucurbitacin B concentrations on the biological ...
Hafiz Kamran Yousaf, Tisheng Shan, Xuewei Chen, Kangsheng Ma, Xueyan Shi, Nicolas Desneux, Antonio Biondi, Xiwu Gao   +7 more
doaj   +1 more source

Inhibition of Telomerase Activity by Cucurbitacin I in Colon Cancer Cell Line, LS174T

Proceedings, 2017
Telomerase activity is dependent on the expression level of human telomerase reverse transcriptase (hTERT) in cancer cells. hTERT messenger ribonucleic acid (mRNA) is expressed in more than 85% of cancer cells, but not in normal human somatic cells ...
Emir Tosun, Ahmet Baysar
doaj   +1 more source

Derivatives of Cucurbitacin-E-glucoside produced by Curvularia lunata NRRL 2178: Anti-inflammatory, antipyretic, antitumor activities, and effect on biochemical parameters

Future Journal of Pharmaceutical Sciences, 2017
Cucurbitacin E glucoside (1) is a tetracyclic triterpenoid glucoside, isolated from Cucurbitaceae plants. In the present study the pharmacological and biochemical effects of cucurbitacin-E-glucoside and two of its microbial transformation derivatives (2 ...
Abdelfattah A. Abdelkhalek, Abdel-Monem M.A. Sharaf, Mohamed Rabie, Hussein I. El-Subbagh   +3 more
doaj   +1 more source