Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. [PDF]
PLoS ONE, 2010 Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism.
David A Knecht +6 more
doaj +5 more sources
Cucurbitacin I Induces Protective Autophagy in Glioblastoma in Vitro and in Vivo [PDF]
Journal of Biological Chemistry, 2014 There is an urgent need for new therapeutic avenues to improve the outcome of patients with glioblastoma multiforme (GBM). Current studies have suggested that cucurbitacin I, a natural selective inhibitor of JAK2/STAT3, has a potent anticancer effect on a variety of cancer cell types.
Yuan G +5 more
exaly +5 more sources
Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. [PDF]
PLoS ONE, 2015 Cucurbitacin I is a naturally occurring triterpenoid derived from Cucurbitaceae family plants that exhibits a number of potentially useful pharmacological and biological activities.
Moon Hee Jeong +6 more
doaj +2 more sources
Profiling and cheminformatics bioprospection of curcurbitacin I and momordin Ic from Momordica balsamina on α-amylase and α-glucosidase [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryMomordica spp. has been traditionally used to manage type 2 diabetes mellitus, but the mechanisms and metabolites remain unclear. This study evaluated the inhibitory potential of Momordica balsamina extracts on α-amylase and α-glucosidase in vitro ...
Viruska Jaichand +4 more
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Pharmacokinetic Profile of Extracts from the Chayote (Sechium edule) H387 07 Hybrid and Phytochemical Characterization of Its Segregant H387 M16 for Potential Therapeutic Applications [PDF]
MoleculesThe hybrid Sechium edule H387 07, commonly known as chayote, has shown potential as an antiproliferative, cytotoxic, and pro-apoptotic agent in the murine leukemia cell lines P388 (macrophagic) and J774 (monocytic) and in the myelomonocytic leukemia cell
Eugenia Elisa Delgado-Tiburcio +6 more
doaj +2 more sources
Ecballium elaterium (L.) A. Rich. (Squirting Cucumber) Plants Cultured Under Different Temperatures: Anatomical and Biochemical Modifications of Their Leaves and the Bioactivity of Leaf Extracts [PDF]
MetabolitesBackground/Objectives: Ecballium elaterium is a widely distributed species and is one of the earliest recorded in traditional medicine. With global temperatures rising, this study aimed to investigate the changes in E.
Aikaterina L. Stefi +9 more
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تشخیص بعض الاحماض الدهنیة ومرکب Cucurbitacin فی مستخلص زیت بعض اجزاء وکالس نبات القرع الجبلی Cucurbita maxima [PDF]
مجلة ابحاث كلية التربية الاساسية, 2021 استخلص زیت نبات القرع الجبلیC.maxima وقدرت نسب وجوده فی الجذور وفی قطع الاوراق والسیقان تحت الفلقیة وفی کالس هذه الاجزاء کنسبة مئویة، وتمکنت الدراسة من تشخیص الاحماض الدهنیة Linolic acid, Oleic acid, Stearic acid, Palmitic acid ، فضلاً عن تشخیص ثلاث ...
islam abdullah
doaj +1 more source
Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]
PeerJ, 2017 Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park +6 more
doaj +1 more source
Nanoprecipitation is more efficient than emulsion solvent evaporation method to encapsulate cucurbitacin I in PLGA nanoparticles [PDF]
Saudi Pharmaceutical Journal, 2014 Aws Alshamsan
exaly +2 more sources