Results 11 to 20 of about 14,776 (215)
Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots [PDF]
Frontiers in Plant Science, 2022 In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but have
Aldo Almeida +7 more
doaj +5 more sources
Cytotoxic Effects of Cucurbitacin I and on Breast Cancer Cells [PDF]
Natural Product Communications, 2018 The objective of this study was to investigate the inhibitory effect of cucurbitacin I (CuI) and Ecballium elaterium L. (fruit juice and chloroform extract) on breast cancer cells (MCF-7 and MDA-MB-231). The CuI content of E.
Kadir Yıilmaz +5 more
doaj +3 more sources
Cucurbitacin I Reverses Tumor-Associated Macrophage Polarization to Affect Cancer Cell Metastasis. [PDF]
Int J Mol Sci, 2023 The tumor microenvironment plays a critical role in tumor progression and immune regulation. As one of the most important components of the tumor microenvironment, macrophages have become a new therapeutic target for inhibiting tumor progression. Despite the well-documented anticancer activity of cucurbitacin I, its effect on macrophages remains ...
Gong X +7 more
europepmc +3 more sources
STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma. [PDF]
Int J Oncol, 2016 The development of clinical agents remains a costly and time-consuming process. Although identification of new uses of existing drugs has been recognized as a more efficient approach for drug discovery than development of novel drugs, little screening of drugs that might be used for a rare malignant tumor such as osteosarcoma (OS) has been performed ...
Oi T +11 more
europepmc +4 more sources
Depolymerization of actin filaments by Cucurbitacin I through binding G-actin. [PDF]
Food Sci Nutr, 2023 AbstractCucurbitacins have high economic value as they are a major source of food and have pharmacological properties. Cucurbitacin I (CuI) is a plant‐derived natural tetracyclic triterpenoid compound that shows an anticancer effect via inhibiting the JAK2‐STAT3 signaling pathway.
Haciosmanoglu Aldogan E +5 more
europepmc +5 more sources
The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A.
Naser Jafargholizadeh +2 more
doaj +1 more source
VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation [PDF]
, 2014 Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
He, Xian-Hui +9 more
core +6 more sources
Plants, 2023 Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize +2 more
doaj +1 more source
Separations, 2021 For the efficient biotransformation of cucurbitacin B 2-o-β-d-glucoside (CuBg) to cucurbitacin B (CuB) in Cucumis melo pedicel extracts, the β-glucosidase gene bglS—consisting of 1344 bp (447 amino acids) from Streptomyces sp.
Jianfeng Mei +5 more
doaj +1 more source
Actin-Aggregating Cucurbitacins from Physocarpus capitatus [PDF]
Journal of Natural Products, 2008 Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
Maloney, Katherine N. +6 more
openaire +3 more sources