Results 21 to 30 of about 14,776 (215)
An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins inIberis amara [PDF]
Molecular Biology and Evolution, 2021 AbstractPieris rapae and Phyllotreta nemorum are Brassicaceae specialists, but do not feed on Iberis amara spp. that contain cucurbitacins. The cucurbitacins are highly oxygenated triterpenoid, occurring widespread in cucurbitaceous species and in a few other plant families. Using de novo assembled transcriptomics from I.
Lemeng Dong +11 more
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Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells
Biochemistry and Biophysics Reports, 2020 Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood.
Isabella J. Brouwer +3 more
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Toxins, 2022 We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in
Souichi Nakashima +6 more
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Effect of Cucurbitacin I on Proliferation and Migration in Colorectal Cancer Cell Line, LS174T
Proceedings, 2017 Cucurbitacin I is a natural component extracted from plants of the Cucurbitaceae family and has shown anti-cancer activity against various types of cancer. The aim of the present study was to investigate its antiproliferative and antimigratory effects on
Emir Tosun, Ahmet Baysar
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Frontiers in Plant Science, 2020 Trichosanthis Radix (TR) is one of the most severely sulfur-fumigated herbs in the market, whose transformation mechanism of chemical compositions and sulfur-fumigation markers of TR have not been clarified.
Chuanzhi Kang +11 more
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Grayanotoxin I Intoxication in Pet Pigs [PDF]
, 2018 Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually due to ingestion of plants of the Ericaceae family, such as Rhododendron. Here, we report the ingestion of Pieris japonica
Köster, Nils +5 more
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Current Issues in Molecular Biology, 2022 Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee +3 more
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Herbivory reduces plant interactions with above- and belowground antagonists and mutualists. [PDF]
, 2012 Herbivores affect plants through direct effects, such as tissue damage, and through indirect effects that alter species interactions. Interactions may be positive or negative, so indirect effects have the potential to enhance or lessen the net impacts of
Adler, L.S. +4 more
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Cucurbitacin I Inhibits Stat3 and Induces Apoptosis in Sézary Cells [PDF]
Journal of Investigative Dermatology, 2008 Sézary syndrome (Sz) is an aggressive cutaneous CD4(+) T-cell lymphoma with tumor cells (Sz cells) localized in the skin, lymph nodes, and peripheral blood. Using western blotting, we demonstrate the expression of phosphorylated (P)-Stat3 in the Sz-derived cell line Seax, and in freshly isolated tumor cells from Sz patients (n=6).
van Kester, Marloes S. +5 more
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Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons [PDF]
, 2014 Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson’s disease (PD).
Arel-Dubeau, Anne-Marie +8 more
core +4 more sources