Results 1 to 10 of about 15,560 (192)

Cucurbitacin E Induces Autophagy-Involved Apoptosis in Intestinal Epithelial Cells [PDF]

Frontiers in Physiology, 2020
Apoptosis plays a crucial role in maintaining the structural and functional integrity of the intestinal epithelial barrier. Autophagy mediates injury to and repair of the intestinal epithelial barrier through multiple pathways in pathophysiological ...
Huapei Song, Hehuan Sui, Hehuan Sui, Hehuan Sui, Qiong Zhang, Pei Wang, Fengjun Wang   +6 more
doaj   +5 more sources

Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells [PDF]

Biochemistry and Biophysics Reports, 2020
Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood.
Isabella J. Brouwer, Jacoba J. Out-Luiting, Maarten H. Vermeer, Cornelis P. Tensen   +3 more
doaj   +5 more sources

Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. [PDF]

Oxid Med Cell Longev, 2014
Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson’s disease (PD).
Arel-Dubeau AM, Longpré F, Bournival J, Tremblay C, Demers-Lamarche J, Haskova P, Attard E, Germain M, Martinoli MG.   +8 more
europepmc   +9 more sources

Cucurbitacin E inhibits cellular proliferation and induces apoptosis in melanoma by suppressing HSDL2 expression [PDF]

Chinese Medicine, 2022
Background Melanoma is among the most aggressive types of skin malignancy and can have an unpredictable clinical course. Exploration of novel therapeutic targets and their regulators remains essential for the prevention and treatment of melanoma. Methods
Wen-Bei Liu, He-Li Wang, Lei Chen, Biao Tang, Guolin Ke, Shuai Wang, Yin-Qiao Sun, Junting Ma, Da-Lun Lyu   +8 more
doaj   +5 more sources

Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes [PDF]

Journal of Translational Medicine, 2023
Background Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of cartilage degeneration.
Lin Wang, Hui Xu, Xin Li, Hongwei Chen, Haigang Zhang, Xunpeng Zhu, Zhijie Lin, Shilei Guo, Zhibo Bao, Haicheng Rui, Wei He, Hui Zhang   +11 more
doaj   +2 more sources

Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells [PDF]

Current Issues in Molecular Biology, 2023
EGFR tyrosine kinase inhibitors (TKIs) are the first-line treatment for advanced EGFR-mutated non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are ineligible for EGFR-TKIs.
Han-Lin Hsu, Bo-Jyun Lin, Yu-Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching-Chiung Wang, Mei-Chuan Chen, Chun-Han Chen   +7 more
doaj   +2 more sources

Cucurbitacin E Inhibits Huh7 Hepatoma Carcinoma Cell Proliferation and Metastasis via Suppressing MAPKs and JAK/STAT3 Pathways [PDF]

Molecules, 2020
Cucurbitacin E (CuE), a highly oxygenated tetracyclic triterpene from Cucurbitaceae, has shown to exhibit potent cytotoxic and anti-proliferative properties against several human cancer cells.
Yang Liu, Heng Yang, Qiang Guo, Tingting Liu, Yong Jiang, Mingbo Zhao, Kewu Zeng, Pengfei Tu   +7 more
doaj   +2 more sources

Cucurbitacin E Alleviates Colonic Barrier Function Impairment and Inflammation Response and Improves Microbial Composition on Experimental Colitis Models [PDF]

Journal of Inflammation Research
Fengxia Zhan,1 Wei Song,2 Yong Fan,3 Fangjian Wang,1 Qian Wang4,5 1Department of Clinical Laboratory, Hospital of Shandong University, Jinan, 250100, People’s Republic of China; 2Key Laboratory of Marine Eco-Environmental Science and Technology, First ...
Zhan F, Song W, Fan Y, Wang F, Wang Q
doaj   +2 more sources

The Mechanisms of Cucurbitacin E as a Neuroprotective and Memory-Enhancing Agent in a Cerebral Hypoperfusion Rat Model: Attenuation of Oxidative Stress, Inflammation, and Excitotoxicity [PDF]

Frontiers in Pharmacology, 2021
Impaired cerebral hemodynamic autoregulation, vasoconstriction, and cardiovascular and metabolic dysfunctions cause cerebral hypoperfusion (CH) that triggers pro-oxidative and inflammatory events.
Zhiyong Liu, Manish Kumar, Sushma Devi, Atul Kabra   +3 more
doaj   +2 more sources

Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. [PDF]

Oncol Rep, 2019
Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist.
Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L.   +9 more
europepmc   +3 more sources