Cucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancer. [PDF]
PLoS ONE, 2014 Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE ...
Yanjie Kong +5 more
doaj +2 more sources
Corrigendum: The Mechanisms of Cucurbitacin E as a Neuroprotective and Memory-Enhancing Agent in a Cerebral Hypoperfusion Rat Model: Attenuation of Oxidative Stress, Inflammation, and Excitotoxicity [PDF]
Frontiers in Pharmacology, 2022 Zhiyong Liu +3 more
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Cell-modified plasmonic interface for the signal-amplified detection of Cucurbitacin E. [PDF]
Biomed Opt Express, 2022 Cucurbitacin E (CuE) plays an important role in anticancer, antichemical carcinogenesis, and body immunity, etc., and the detection of its concentration is meaningful to pharmacological studies and clinical applications. However, the small molecular weight of CuE makes direct detection difficult through a surface plasmon resonance (SPR) sensor. In this
Chen Y +7 more
europepmc +3 more sources
Determination of cucurbitacin E in some selected herbs of ayurvedic importance through RP-HPLC. [PDF]
J Ayurveda Integr Med, 2020 The consumption of the fruits of cucurbitaceae plants is widely popular among Indians due to their various nutritional and medicinal purposes. Some of these plants are well reported in Ayurveda due to their potential therapeutic importance. In particular, the plants of this family are well-characterized by the presence of its bitter principle ...
Chanda J, Biswas S, Kar A, Mukherjee PK.
europepmc +3 more sources
The natural product cucurbitacin E inhibits depolymerization of actin filaments. [PDF]
ACS Chem Biol, 2012 Although small molecule actin modulators have been widely used as research tools, only one cell-permeable small molecule inhibitor of actin depolymerization (jasplakinolide) is commercially available. We report that the natural product cucurbitacin E inhibits actin depolymerization and show that its mechanism of action is different from jasplakinolide.
Sörensen PM +6 more
europepmc +5 more sources
Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]
PeerJ, 2017 Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang +3 more
doaj +2 more sources
تشخیص بعض الاحماض الدهنیة ومرکب Cucurbitacin فی مستخلص زیت بعض اجزاء وکالس نبات القرع الجبلی Cucurbita maxima [PDF]
مجلة ابحاث كلية التربية الاساسية, 2021 استخلص زیت نبات القرع الجبلیC.maxima وقدرت نسب وجوده فی الجذور وفی قطع الاوراق والسیقان تحت الفلقیة وفی کالس هذه الاجزاء کنسبة مئویة، وتمکنت الدراسة من تشخیص الاحماض الدهنیة Linolic acid, Oleic acid, Stearic acid, Palmitic acid ، فضلاً عن تشخیص ثلاث ...
islam abdullah
doaj +1 more source
Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)
Frontiers in Plant Science, 2022 Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao +9 more
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The cucurbitacins D, E, and I from Ecballium elaterium (L.) upregulate the LC3 gene and induce cell-cycle arrest in human gastric cancer cell line AGS [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A.
Naser Jafargholizadeh +2 more
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VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation [PDF]
, 2014 Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
He, Xian-Hui +9 more
core +6 more sources