Results 31 to 40 of about 15,560 (192)
Journal of Insect Physiology, 2021 In insects, some sterols are essential not only for cell membrane homeostasis, but for biosynthesis of the steroid hormone ecdysone. Dietary sterols are required for insect development because insects cannot synthesize sterols de novo. Therefore, sterol-like compounds that can compete with essential sterols are good candidates for insect growth ...
Toyofuku, Miwako +8 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2022 Background In silico studies further provided predictive binding properties of selected ligands for inhibition of target protein. In the study, molecular binding poses of Cucurbitacin-E and antioxidant enzymes (glutathione-S-transferase (GST), superoxide
Fahriye Sümer Ercan +2 more
doaj +1 more source
Plants, 2023 Bottle gourd [Lagenaria siceraria (Molina) Standl.]) is a relatively drought-tolerant cucurbit due to the high composition of unique biochemical compositions, including cucurbitacin.
Phumzile Mkhize +2 more
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The Effects of Cucurbitacin E on Two Lymphocyte Models [PDF]
Pharmaceutical Biology, 2004 Cucurbitacin E (CuE), like other cucurbitacins, is a potential anti-neoplastic agent. The aim of the present study was to investigate the in vitro effects of CuE on phytohaemagglutinin (PHA)-activated and unstimulated lymphocytes. CuE did not produce any significant cytotoxic effects on the two models.
E. Attard +3 more
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Metabolic engineering of cucurbitacins in Cucurbita pepo hairy roots
Frontiers in Plant Science, 2022 In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but have
Aldo Almeida +7 more
doaj +1 more source
Bioassay-guided isolation of cytotoxic constituents from the flowers of Aquilaria sinensis
Natural Products and Bioprospecting, 2022 Bioassay-guided fractionation of the EtOH extract from the flowers of Aquilaria sinensis (Lour.) Spreng. (Thymelaeaceae) led to the isolation of a new cucurbitane-type triterpenoid, aquilarolide A (1), along with five known compounds (2–6). The structure
Jun Yang +5 more
doaj +1 more source
Cucurbitacin E Targets Proliferating Endothelia
Journal of Surgical Research, 1997 Tumor vasculature offers a target for drugs directed against proliferating endothelia. We hypothesized that cucurbitacin E (CuE), an actin-disrupting agent, would preferentially inhibit proliferating vs. quiescent endothelia. Log-phase and confluent ECV304 and HUVEC human endothelial cells were exposed to 10-200 nM CuE for 1-96 hr, and toxicity was ...
M D, Duncan, K L, Duncan
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Cucurbitacin E induces apoptosis of human prostate cancer cells via cofilin-1 and mTORC1. [PDF]
Oncol Lett, 2017 Cucurbitacin E is an important member of the cucurbitacin family and exhibits inhibitory effects in various types of cancer. Cucurbitacin is a potential antineoplastic drug; however, its anticancer effect in human prostate cancer (PC) remains unknown.
He X, Gao Q, Qiang Y, Guo W, Ma Y.
europepmc +4 more sources
Herbivory reduces plant interactions with above- and belowground antagonists and mutualists. [PDF]
, 2012 Herbivores affect plants through direct effects, such as tissue damage, and through indirect effects that alter species interactions. Interactions may be positive or negative, so indirect effects have the potential to enhance or lessen the net impacts of
Adler, L.S. +4 more
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Grayanotoxin I Intoxication in Pet Pigs [PDF]
, 2018 Contaminated honey is a common cause of grayanotoxin intoxication in humans. Intoxication of animals, especially cattle, is usually due to ingestion of plants of the Ericaceae family, such as Rhododendron. Here, we report the ingestion of Pieris japonica
Köster, Nils +5 more
core +1 more source