Cucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin [PDF]
Frontiers in Physiology, 2018 The proliferation and migration of intestinal epithelial cell is important to the barrier integrity of intestinal epithelium. Cucurbitacin E (CuE) is one of the tetracyclic triterpenoids extracted from the cucurbitaceae that has been shown to inhibit ...
Huapei Song +5 more
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Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity. [PDF]
PLoS ONE, 2015 Cucurbitacins, the natural triterpenoids possessing many biological activities, have been reported to suppress the mTORC1/p70S6K pathway and to induce autophagy. However, the correlation between such activities is largely unknown.
Qing-Bing Zha +9 more
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Cucurbitacin E Suppresses Adipogenesis and Lipid Accumulation in 3T3-L1 Adipocytes Without Cytotoxicity [PDF]
BiomedicinesBackground: Cucurbitacin E (CuE), a natural tetracyclic triterpenoid compound extracted from the melon stems of Cucurbitaceae plants, has been reported to exhibit anti-inflammatory and anti-cancer properties, along with the ability to enhance cellular ...
Tien-Chou Soong +3 more
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Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities [PDF]
Pharmaceutical Sciences, 2021 For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed ...
Moazzameh Ramezani +3 more
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Study on the chemotherapeutic effect and mechanism of cucurbitacin E on laryngeal cancer stem cells [PDF]
Laryngoscope Investigative Otolaryngology, 2022 Objectives Study on the chemotherapeutic effect and mechanism of cucurbitacin E (CuE) on laryngeal cancer stem cells. Methods We used flow cytometry to sort out CD133+ laryngeal cancer stem cells; trypan blue rejection assay to detect the survival rate ...
Xuelian Jiang +5 more
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Comparison between the effects of potassium phosphite and chitosan on changes in the concentration of Cucurbitacin E and on antibacterial property of Cucumis sativus [PDF]
BMC Complementary and Alternative Medicine, 2017 Background Cucurbitacins are mostly found in the members of the family Cucurbitaceae and are responsible for the bitter taste of cucumber. Pharmacological activities such as anti-bacterial and anti-tumor effects have been attributed to these structurally
Moazzameh Ramezani +2 more
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Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS [PDF]
Frontiers in PharmacologyIntroductionCucurbitacin, a class of triterpenoid compounds isolated from Pedicellus Melo, possesses various biological activities and is the primary active component of cucurbitacin tablets (CUT) used to treat chronic hepatitis and primary liver cancer.
Chun-nan Zhang +8 more
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Dietary cucurbitacin E reduces high-strength altitude training induced oxidative stress, inflammation and immunosuppression [PDF]
Anais da Academia Brasileira de Ciências, 2020 Professional athletes conduct high-intensitive hypoxic training often accompanied by the increase of many inflammatory-related cytokines and immunosuppression.
HEZHI XIE +5 more
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Cucurbitacin E inhibits M1 macrophage polarization and attenuates rheumatoid arthritis: a multi-omics analysis and experimental validation [PDF]
Journal of Orthopaedic Surgery and ResearchBackground Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by joint inflammation and destruction. Current treatments often have side effects and resistance.
Haolan Xiong +5 more
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Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. [PDF]
PLoS ONE, 2017 Several members of cucurbitaceae family have been reported to regulate growth of cancer by interfering with STAT3 signaling. In the present study, we investigated the unique role and molecular mechanism of cucurbitacins (Cucs) in reducing symptoms of ...
Munazza Murtaza +7 more
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